1, 3, 4-Oxadiazole analogues - Maheshwari, Radhika;Chawla, Pooja;Saraf, Shubhini
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Heterocyclic compounds have been well researched and still continue to provide solutions to innumerable problems faced by mankind. One of such problems is increasing resistance of microbes against existing antibiotics. Often, infection is found to be associated with inflammation. 1, 3, 4-oxadiazoles have been explored by a number of scientists worldwide these derivatives have emerged as potential lead molecules for development of newer antimicrobial and anti-inflammatory agents. The present work reports the synthesis and evaluation of some 2, 5-disubstituted 1, 3, 4-oxadiazoles and their…mehr

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Produktbeschreibung
Heterocyclic compounds have been well researched and still continue to provide solutions to innumerable problems faced by mankind. One of such problems is increasing resistance of microbes against existing antibiotics. Often, infection is found to be associated with inflammation. 1, 3, 4-oxadiazoles have been explored by a number of scientists worldwide these derivatives have emerged as potential lead molecules for development of newer antimicrobial and anti-inflammatory agents. The present work reports the synthesis and evaluation of some 2, 5-disubstituted 1, 3, 4-oxadiazoles and their pharmacological evaluation for antimicrobial, analgesic and anti-inflammatory activities. A fair number of compounds were found to have good anti-inflammatory activity in carrageenan-induced rat paw oedema test, while all the compounds showed significant antibacterial activity. The contents of this book must make an excellent read for those interested in heterocyclic research.
Autorenporträt
Radhika Maheshwari did her M. Pharm. (Pharmaceutical Chemistry) from Faculty of Pharmacy, BBDNITM, Lucknow (India) and B. Pharm. from Guru Nanak Dev University, Amritsar (India). She has active interest in synthetic medicinal chemistry and has published articles on 1,3,4-oxadiazole nucleus.