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The 10th Anniversary of Biomedicines-Translational Laboratory and Experimental Medicine for the Sake of Neurological Diseases and Mental Illnesses features a collection of 21 groundbreaking papers commemorating a decade of pioneering research into the complexities of the human mind, neurological diseases, and mental illnesses. This reprint explores the complex interactions that occur within the human brain, including neuroplasticity, cognitive responses, and the influence of aging and pathological conditions on behavior. Researchers and clinicians have dedicated themselves to bridging the gap between laboratory discoveries and clinical applications, unraveling the mysteries of brain function and mental health, and proposing novel therapeutic approaches and potential advances in the field. This articles included in this Special Issue crucially elucidate the mechanisms that underpin neurological disorders and mental illnesses by investigating neural circuits, plasticity, and brain adaptation. From studying the brain's ability to recover after a stroke to investigating the relationship between neural activity and cognitive function, this collection of papers exemplifies the unwavering dedication and innovation of biomedicine. As we commemorate a decade of groundbreaking research, these findings pave the way for future studies that aim to enhance the lives of people suffering from neurological conditions and mental health illnesses.