5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents - Sidat, Parin S;Noolvi, Malleshappa;Beldar, Vishal G
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In search of new anticancer agents we have reported the synthesis of some 1,3,4-thiadiazoles. While designing target molecules, we studied some reported HDAC (Histone deacetylases) inhibitor and from that we have used some fragments to design new target molecules. The reaction was monitored by TLC using suitable mobile phase and also determined the melting point of the Thiadiazole analogues. It is found that they were different from each other's. Furthermore also characterized and confirmed by IR, 1H-NMR, and Mass spectral. For anticancer activity, all the selected compounds were submitted to…mehr

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Produktbeschreibung
In search of new anticancer agents we have reported the synthesis of some 1,3,4-thiadiazoles. While designing target molecules, we studied some reported HDAC (Histone deacetylases) inhibitor and from that we have used some fragments to design new target molecules. The reaction was monitored by TLC using suitable mobile phase and also determined the melting point of the Thiadiazole analogues. It is found that they were different from each other's. Furthermore also characterized and confirmed by IR, 1H-NMR, and Mass spectral. For anticancer activity, all the selected compounds were submitted to NCI (National Cancer Institute) for in vitro anticancer activity. Primary in vitro one dose anticancer assay was performed in full NCI 60 cell panel in accordance with the protocol of the NCI, USA. The compound 5(a) and (6b) showed good activity against the all cancer cell lines at NCI, USA
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Autorenporträt
Parin S. Sidat is working as Assistant Professor in Department of Pharmaceutical chemistry at Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat. She has completed M Pharm in Pharmaceutical Chemistry from Gujarat Technological University and also received two gold medals in Master of Pharmacy. She has 2 year's experience in Cancer Research.