50 Studies Every Neonatologist Should Know
Herausgeber: Zupancic, John; Kirpalani, Haresh; Schmidt, Barbara; Soll, Roger F; Hay, Susanne
50 Studies Every Neonatologist Should Know
Herausgeber: Zupancic, John; Kirpalani, Haresh; Schmidt, Barbara; Soll, Roger F; Hay, Susanne
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50 Studies Every Neonatologist Should Know presents a selection of seminal trials in neonatology, including both cornerstones of practice and frontiers in trial design. The included trials cover a broad range of care topics in neonatology, as well as important learning points in a number of dimensions. The text explores each trial in a dedicated chapter, with a concise summary of methods and results, accompanied by a brief discussion of special considerations, including risks of bias, interpretation, and implications for practice. Additionally, there is a short interview with the trialist (or…mehr
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50 Studies Every Neonatologist Should Know presents a selection of seminal trials in neonatology, including both cornerstones of practice and frontiers in trial design. The included trials cover a broad range of care topics in neonatology, as well as important learning points in a number of dimensions. The text explores each trial in a dedicated chapter, with a concise summary of methods and results, accompanied by a brief discussion of special considerations, including risks of bias, interpretation, and implications for practice. Additionally, there is a short interview with the trialist (or an editorial commentary) at the end of each chapter, to give a flavor of the ongoing conversation after trial publication. It is a must-read for neonatologists, trainees, or anyone involved in neonatal care or trial design.
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Produktdetails
- Produktdetails
- Verlag: Oxford University Press
- Seitenzahl: 368
- Erscheinungstermin: 20. September 2024
- Englisch
- Abmessung: 233mm x 155mm x 24mm
- Gewicht: 534g
- ISBN-13: 9780197646953
- ISBN-10: 0197646956
- Artikelnr.: 67734253
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- gpsr@libri.de
- Verlag: Oxford University Press
- Seitenzahl: 368
- Erscheinungstermin: 20. September 2024
- Englisch
- Abmessung: 233mm x 155mm x 24mm
- Gewicht: 534g
- ISBN-13: 9780197646953
- ISBN-10: 0197646956
- Artikelnr.: 67734253
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- gpsr@libri.de
Susanne Hay, MD is an academic neonatologist with an interest in evidence-based care. She graduated from Harvard College and earned a medical degree from Columbia College of Physicians & Surgeons. She went on to train in pediatrics in the Boston Combined Residency Program, and then completed the Harvard Combined Fellowship in Neonatology. Dr. Hay is now an attending neonatologist at the Beth Israel Deaconess Medical Center and an instructor in pediatrics at the Harvard Medical School. Her primary research focus is data synthesis, evaluating the neonatal research landscape and how we know what we know, as well as how we might address inefficiencies. Roger F. Soll, MD is the H. Wallace Professor of Neonatology at the University of Vermont, Vice President of the Vermont Oxford Network (VON) and Director of the VON Institute for Evidence Based Practice. He is the author of numerous peer reviewed articles and book chapters on the subject of surfactant replacement therapy and evidence-based medicine. Dr. Soll graduated from Cornell University in 1975 and received his M.D. degree from the University of Health Sciences/Chicago Medical School in 1978. He completed his residency training in Pediatrics at Bellevue Hospital/New York University Medical Center in 1981. After 2 years with the Public Health Service, Dr. Soll returned to academic training. He completed the fellowship in Neonatal Perinatal Medicine at the University of Vermont in 1985 and has remained in Vermont ever since. Barbara Schmidt, MD, MSc is a neonatologist and clinical epidemiologist who led three large international neonatal randomized trials with clinically important, long-term outcomes: (1) Trial of Indomethacin Prophylaxis in Preterms (TIPP); (2) Caffeine for Apnea of Prematurity (CAP) Trial; and (3) Canadian Oxygen Trial (COT). Dr. Schmidt has received the highest honors in her specialty, including the Douglas K Richardson Award from the Society for Pediatric Research, the Virginia Apgar Award from the American Academy of Pediatrics, and the Arvo Ylppö Medal from the Finnish Pediatric Research Foundation. She is a member of the Order of Canada. Haresh Kirpalani, MD, MSc is a neonatologist and clinical epidemiologist. He led three large randomized trials with clinically important outcomes: (1) Nasal Intermittent Positive-Pressure Ventilation (NIPPV) (2) Transfusion of Prematures (TOP); and (3) Sustained Aeration of Infant Lungs (SAIL). He has received several prizes for teaching and mentorship, for clinical neonatology and principles of evidence based practice. He was a founding member of 'Evidence Based Neonatology'. He has been a co-chair of the forum 'Hot Topics for Neonatology' for 10 years. In 2022 he was awarded the William A Silverman Lectureship Award, of the American Academy of Pediatrics. John. Zupancic, MD, MS, ScD is Associate Professor of Pediatrics at Harvard Medical School and Associate Chief of Neonatology at Beth Israel Deaconess Medical Center, and serves as the Director of the Exploring Pathways to Optimize Child Health (EPOCH) program, which oversees neonatology clinical research at that institution. His own scholarly work seeks to improve the efficiency with which scarce resources are used in improving the health of children, and in particular, newborns. Dr. Zupancic is also involved in various epidemiologic and health services investigations, including the Neonatology Canon Project, a large-scale systematic review of all randomized controlled trials in neonatology over a thirty-year period. He was the recipient of the Massachusetts Medical Society's Henry Ingersoll Bowditch Award for Excellence in Public Health in 2020.
* Preface from the Series Editor
* Preface
* Contributors
* Intrapartum Care
* 1. A Controlled Trial of Antepartum Glucocorticoid Treatment for
Prevention of the Respiratory Distress Syndrome in Premature Infants
* Sarah D. McDonald
* 2. Prevention of Early-Onset Neonatal Group B Streptococcal Disease
with Selective Intrapartum Chemoprophylaxis
* Megan J. Turner and Clyde J. Wright
* 3. Reduction of Maternal-Infant Transmission of Human
Immunodeficiency Virus Type 1 with Zidovudine Treatment
* Wes Onland and Anton H. van Kaam
* 4. A Randomized, Controlled Trial of Magnesium Sulfate for the
Prevention of Cerebral Palsy: The BEAM Trial
* Elizabeth Foglia
* Resuscitation
* 5. Resuscitation of Asphyxiated Newborn Infants with Room Air or
Oxygen: The Resair 2 Trial
* Elizabeth Baker and Peter G. Davis
* 6. Delivery Room Management Of The Apparently Vigorous
Meconium-Stained Neonate
* Charles Christoph Roehr
* 7. Randomized Trial of Occlusive Wrap for Heat Loss Prevention in
Preterm Infants: The HeLP Trial
* Anup Katheria
* 8. Association of Umbilical Cord Milking Versus Delayed Umbilical
Cord Clamping with Death or Severe Intraventricular Hemorrhage among
Preterm Infants: The PREMOD2 Trial
* Seh Hyun Kim and Han-Suk Kim
* 9. Effect of Sustained Inflations Versus Intermittent Positive
Pressure Ventilation on Bronchopulmonary Dysplasia or Death among
Extremely Preterm Infants: The SAIL Trial
* Susanne Hay and John Zupancic
* Cardiovascular
* 10. Effects of Indomethacin in Premature Infants with Patent Ductus
Arteriosus
* Souvik Mitra
* 11. Extracorporeal Circulation in Neonatal Respiratory Failure
* Elizabeth Baker and Peter G. Davis
* 12. UK Collaborative Randomised Trial of Neonatal Extracorporeal
Membrane Oxygenation
* Brianna Liberio and Clyde J. Wright
* 13. Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants
with Hypoxic Respiratory Failure: The NINOS Trial
* Dirk Bassler
* Respiratory
* 14. Prevention of Neonatal Respiratory Distress Syndrome by Tracheal
Instillation of Surfactant
* Colm P.F. O'Donnell
* 15. Collaborative Quality Improvement to Promote Evidence Based
Surfactant for Preterm Infants: A Cluster Randomised Trial
* Ashraf Kharrat and Prakesh S. Shah
* 16. Pressure-Regulated Volume Control Ventilation Versus Synchronized
Intermittent Mandatory Ventilation for Very Low-Birth-Weight Infants
* Erik A. Jensen
* 17. Long-Term Effects of Caffeine Therapy for Apnea of Prematurity:
The CAP Trial
* Dirk Bassler
* 18. Outcome at Two Years of Age of Infants from The DART Study: A
Multicenter, International, Randomised, Controlled Trial of Low-Dose
Dexamethasone
* Anton H. van Kaam and Wes Onland
* 19. Early CPAP Versus Surfactant in Extremely Preterm Infants: The
SUPPORT Trial
* Brett J. Manley
* 20. Target Ranges of Oxygen Saturation in Extremely Preterm Infants:
The SUPPORT Trial
* James I. Hagadorn
* 21. A Trial Comparing Noninvasive Ventilation Strategies in Preterm
Infants
* Brett J. Manley
* 22. High-Flow Nasal Cannulae in Very Preterm Infants after
Extubation: The HIPERSPACE Trial
* Charles Christoph Roehr
* Nutrition
* 23. Randomised Trial of Early Diet in Preterm Babies and Later
Intelligence Quotient
* Michelle Fernandes and Jon Dorling
* 24. Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants
* Susanne Hay and Axel R. Franz
* 25. Promotion of Breastfeeding Intervention Trial: The PROBIT Trial
* Nicholas D. Embleton
* 26. Dextrose Gel for Neonatal Hypoglycemia: The Sugar Babies Trial
* Adel Mohamed, Jyotsna Shah, and Prakesh S. Shah
* 27. Effect of Supplemental Donor Human Milk Compared with Preterm
Formula on Neurodevelopment of Very Low-Birth-Weight Infants at 18
Months: The DOMINO Trial
* Nicholas D. Embleton
* Thermal
* 28. The Influence of the Thermal Environment upon the Survival of
Newly Born Premature Infants
* David Osborn
* 29. Kangaroo Mother Versus Traditional Care for Newborn Infants.
* Srinivas Murki
* Infectious Disease / Immunology
* 30. Palivizumab, A Humanized Respiratory Syncytial Virus Monoclonal
Antibody, Reduces Hospitalization from Respiratory Syncytial Virus
Infection in High-Risk Infants: The IMpact-RSV Trial
* Brian C. King
* 31. Probiotic Effects on Late-Onset Sepsis in Very Preterm Infants:
The ProPrems Trial
* Deena Thomas and M. Jeeva Shankar
* 32. Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease
* Li Ma
* Hematology
* 33. Hemorrhagic Disease of the Newborn
* Anna E. Curley
* 34. Effects of Early Erythropoietin Therapy on the Transfusion
Requirements of Preterm Infants Below 1250 Grams Birth Weight
* Anna E. Curley
* 35. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm
Infants: The TOP Trial
* Axel R. Franz
* 36. A Randomized Trial of Erythropoietin for Neuroprotection in
Preterm Infants: The PENUT Trial
* Nicholas D. Embleton
* 37. Randomized Trial of Platelet-Transfusion Thresholds in Neonates:
The PlaNeT Trial
* Ravi Mangal Patel
* Ophthalmology
* 38. Multicenter Trial of Cryotherapy for Retinopathy of Prematurity,
Preliminary Results: The CRYO-ROP Trial
* James I. Hagadorn
* 39. Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of
Prematurity, Primary Outcomes: The STOP-ROP Trial
* Souvik Mitra
* 40. Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of
Prematurity: The BEAT-ROP Trial
* Brian C. King
* Neurology
* 41. Long-Term Effects of Indomethacin Prophylaxis in
Extremely-Low-Birth-Weight Infants: The TIPP Trial
* Peter W. Fowlie and William McGuire
* 42. Effects of Morphine Analgesia in Ventilated Preterm Neonates,
Primary Outcomes: The NEOPAIN Trial
* Souvik Mitra
* 43. Whole-Body Hypothermia for Neonates with Hypoxic-Ischemic
Encephalopathy
* Anton H. van Kaam and Wes Onland
* 44. Effectiveness of Sucrose Analgesia in Newborns Undergoing Painful
Medical Procedures
* David Osborn
* 45. A Randomized Trial of Prenatal Versus Postnatal Repair of
Myelomeningocele: The MOMS Trial
* Sara DeMauro
* 46. Neurodevelopmental Outcome at Five Years of Age after General
Anaesthesia or Awake-Regional Anaesthesia In Infancy: The GAS Trial
* Sara B. DeMauro
* 47. Levetiracetam Versus Phenobarbital for Neonatal Seizures: The
NEOLEV2 Trial
* Stefan Johansson
* 48. Hypothermia for Moderate or Severe Neonatal Encephalopathy in
Low-Income and Middle-Income Countries: The HELIX Trial
* Srinivas Murki
* Health Services
* 49. Newborn-Care Training and Perinatal Mortality in Developing
Countries: The First Breath Trial
* Danielle E.Y. Ehret
* 50. Effectiveness of Family Integrated Care in Neonatal Intensive
Care Units on Infant and Parent Outcomes
* Evangelia Myttaraki and Chris Gale
* Preface
* Contributors
* Intrapartum Care
* 1. A Controlled Trial of Antepartum Glucocorticoid Treatment for
Prevention of the Respiratory Distress Syndrome in Premature Infants
* Sarah D. McDonald
* 2. Prevention of Early-Onset Neonatal Group B Streptococcal Disease
with Selective Intrapartum Chemoprophylaxis
* Megan J. Turner and Clyde J. Wright
* 3. Reduction of Maternal-Infant Transmission of Human
Immunodeficiency Virus Type 1 with Zidovudine Treatment
* Wes Onland and Anton H. van Kaam
* 4. A Randomized, Controlled Trial of Magnesium Sulfate for the
Prevention of Cerebral Palsy: The BEAM Trial
* Elizabeth Foglia
* Resuscitation
* 5. Resuscitation of Asphyxiated Newborn Infants with Room Air or
Oxygen: The Resair 2 Trial
* Elizabeth Baker and Peter G. Davis
* 6. Delivery Room Management Of The Apparently Vigorous
Meconium-Stained Neonate
* Charles Christoph Roehr
* 7. Randomized Trial of Occlusive Wrap for Heat Loss Prevention in
Preterm Infants: The HeLP Trial
* Anup Katheria
* 8. Association of Umbilical Cord Milking Versus Delayed Umbilical
Cord Clamping with Death or Severe Intraventricular Hemorrhage among
Preterm Infants: The PREMOD2 Trial
* Seh Hyun Kim and Han-Suk Kim
* 9. Effect of Sustained Inflations Versus Intermittent Positive
Pressure Ventilation on Bronchopulmonary Dysplasia or Death among
Extremely Preterm Infants: The SAIL Trial
* Susanne Hay and John Zupancic
* Cardiovascular
* 10. Effects of Indomethacin in Premature Infants with Patent Ductus
Arteriosus
* Souvik Mitra
* 11. Extracorporeal Circulation in Neonatal Respiratory Failure
* Elizabeth Baker and Peter G. Davis
* 12. UK Collaborative Randomised Trial of Neonatal Extracorporeal
Membrane Oxygenation
* Brianna Liberio and Clyde J. Wright
* 13. Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants
with Hypoxic Respiratory Failure: The NINOS Trial
* Dirk Bassler
* Respiratory
* 14. Prevention of Neonatal Respiratory Distress Syndrome by Tracheal
Instillation of Surfactant
* Colm P.F. O'Donnell
* 15. Collaborative Quality Improvement to Promote Evidence Based
Surfactant for Preterm Infants: A Cluster Randomised Trial
* Ashraf Kharrat and Prakesh S. Shah
* 16. Pressure-Regulated Volume Control Ventilation Versus Synchronized
Intermittent Mandatory Ventilation for Very Low-Birth-Weight Infants
* Erik A. Jensen
* 17. Long-Term Effects of Caffeine Therapy for Apnea of Prematurity:
The CAP Trial
* Dirk Bassler
* 18. Outcome at Two Years of Age of Infants from The DART Study: A
Multicenter, International, Randomised, Controlled Trial of Low-Dose
Dexamethasone
* Anton H. van Kaam and Wes Onland
* 19. Early CPAP Versus Surfactant in Extremely Preterm Infants: The
SUPPORT Trial
* Brett J. Manley
* 20. Target Ranges of Oxygen Saturation in Extremely Preterm Infants:
The SUPPORT Trial
* James I. Hagadorn
* 21. A Trial Comparing Noninvasive Ventilation Strategies in Preterm
Infants
* Brett J. Manley
* 22. High-Flow Nasal Cannulae in Very Preterm Infants after
Extubation: The HIPERSPACE Trial
* Charles Christoph Roehr
* Nutrition
* 23. Randomised Trial of Early Diet in Preterm Babies and Later
Intelligence Quotient
* Michelle Fernandes and Jon Dorling
* 24. Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants
* Susanne Hay and Axel R. Franz
* 25. Promotion of Breastfeeding Intervention Trial: The PROBIT Trial
* Nicholas D. Embleton
* 26. Dextrose Gel for Neonatal Hypoglycemia: The Sugar Babies Trial
* Adel Mohamed, Jyotsna Shah, and Prakesh S. Shah
* 27. Effect of Supplemental Donor Human Milk Compared with Preterm
Formula on Neurodevelopment of Very Low-Birth-Weight Infants at 18
Months: The DOMINO Trial
* Nicholas D. Embleton
* Thermal
* 28. The Influence of the Thermal Environment upon the Survival of
Newly Born Premature Infants
* David Osborn
* 29. Kangaroo Mother Versus Traditional Care for Newborn Infants.
* Srinivas Murki
* Infectious Disease / Immunology
* 30. Palivizumab, A Humanized Respiratory Syncytial Virus Monoclonal
Antibody, Reduces Hospitalization from Respiratory Syncytial Virus
Infection in High-Risk Infants: The IMpact-RSV Trial
* Brian C. King
* 31. Probiotic Effects on Late-Onset Sepsis in Very Preterm Infants:
The ProPrems Trial
* Deena Thomas and M. Jeeva Shankar
* 32. Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease
* Li Ma
* Hematology
* 33. Hemorrhagic Disease of the Newborn
* Anna E. Curley
* 34. Effects of Early Erythropoietin Therapy on the Transfusion
Requirements of Preterm Infants Below 1250 Grams Birth Weight
* Anna E. Curley
* 35. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm
Infants: The TOP Trial
* Axel R. Franz
* 36. A Randomized Trial of Erythropoietin for Neuroprotection in
Preterm Infants: The PENUT Trial
* Nicholas D. Embleton
* 37. Randomized Trial of Platelet-Transfusion Thresholds in Neonates:
The PlaNeT Trial
* Ravi Mangal Patel
* Ophthalmology
* 38. Multicenter Trial of Cryotherapy for Retinopathy of Prematurity,
Preliminary Results: The CRYO-ROP Trial
* James I. Hagadorn
* 39. Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of
Prematurity, Primary Outcomes: The STOP-ROP Trial
* Souvik Mitra
* 40. Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of
Prematurity: The BEAT-ROP Trial
* Brian C. King
* Neurology
* 41. Long-Term Effects of Indomethacin Prophylaxis in
Extremely-Low-Birth-Weight Infants: The TIPP Trial
* Peter W. Fowlie and William McGuire
* 42. Effects of Morphine Analgesia in Ventilated Preterm Neonates,
Primary Outcomes: The NEOPAIN Trial
* Souvik Mitra
* 43. Whole-Body Hypothermia for Neonates with Hypoxic-Ischemic
Encephalopathy
* Anton H. van Kaam and Wes Onland
* 44. Effectiveness of Sucrose Analgesia in Newborns Undergoing Painful
Medical Procedures
* David Osborn
* 45. A Randomized Trial of Prenatal Versus Postnatal Repair of
Myelomeningocele: The MOMS Trial
* Sara DeMauro
* 46. Neurodevelopmental Outcome at Five Years of Age after General
Anaesthesia or Awake-Regional Anaesthesia In Infancy: The GAS Trial
* Sara B. DeMauro
* 47. Levetiracetam Versus Phenobarbital for Neonatal Seizures: The
NEOLEV2 Trial
* Stefan Johansson
* 48. Hypothermia for Moderate or Severe Neonatal Encephalopathy in
Low-Income and Middle-Income Countries: The HELIX Trial
* Srinivas Murki
* Health Services
* 49. Newborn-Care Training and Perinatal Mortality in Developing
Countries: The First Breath Trial
* Danielle E.Y. Ehret
* 50. Effectiveness of Family Integrated Care in Neonatal Intensive
Care Units on Infant and Parent Outcomes
* Evangelia Myttaraki and Chris Gale
* Preface from the Series Editor
* Preface
* Contributors
* Intrapartum Care
* 1. A Controlled Trial of Antepartum Glucocorticoid Treatment for
Prevention of the Respiratory Distress Syndrome in Premature Infants
* Sarah D. McDonald
* 2. Prevention of Early-Onset Neonatal Group B Streptococcal Disease
with Selective Intrapartum Chemoprophylaxis
* Megan J. Turner and Clyde J. Wright
* 3. Reduction of Maternal-Infant Transmission of Human
Immunodeficiency Virus Type 1 with Zidovudine Treatment
* Wes Onland and Anton H. van Kaam
* 4. A Randomized, Controlled Trial of Magnesium Sulfate for the
Prevention of Cerebral Palsy: The BEAM Trial
* Elizabeth Foglia
* Resuscitation
* 5. Resuscitation of Asphyxiated Newborn Infants with Room Air or
Oxygen: The Resair 2 Trial
* Elizabeth Baker and Peter G. Davis
* 6. Delivery Room Management Of The Apparently Vigorous
Meconium-Stained Neonate
* Charles Christoph Roehr
* 7. Randomized Trial of Occlusive Wrap for Heat Loss Prevention in
Preterm Infants: The HeLP Trial
* Anup Katheria
* 8. Association of Umbilical Cord Milking Versus Delayed Umbilical
Cord Clamping with Death or Severe Intraventricular Hemorrhage among
Preterm Infants: The PREMOD2 Trial
* Seh Hyun Kim and Han-Suk Kim
* 9. Effect of Sustained Inflations Versus Intermittent Positive
Pressure Ventilation on Bronchopulmonary Dysplasia or Death among
Extremely Preterm Infants: The SAIL Trial
* Susanne Hay and John Zupancic
* Cardiovascular
* 10. Effects of Indomethacin in Premature Infants with Patent Ductus
Arteriosus
* Souvik Mitra
* 11. Extracorporeal Circulation in Neonatal Respiratory Failure
* Elizabeth Baker and Peter G. Davis
* 12. UK Collaborative Randomised Trial of Neonatal Extracorporeal
Membrane Oxygenation
* Brianna Liberio and Clyde J. Wright
* 13. Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants
with Hypoxic Respiratory Failure: The NINOS Trial
* Dirk Bassler
* Respiratory
* 14. Prevention of Neonatal Respiratory Distress Syndrome by Tracheal
Instillation of Surfactant
* Colm P.F. O'Donnell
* 15. Collaborative Quality Improvement to Promote Evidence Based
Surfactant for Preterm Infants: A Cluster Randomised Trial
* Ashraf Kharrat and Prakesh S. Shah
* 16. Pressure-Regulated Volume Control Ventilation Versus Synchronized
Intermittent Mandatory Ventilation for Very Low-Birth-Weight Infants
* Erik A. Jensen
* 17. Long-Term Effects of Caffeine Therapy for Apnea of Prematurity:
The CAP Trial
* Dirk Bassler
* 18. Outcome at Two Years of Age of Infants from The DART Study: A
Multicenter, International, Randomised, Controlled Trial of Low-Dose
Dexamethasone
* Anton H. van Kaam and Wes Onland
* 19. Early CPAP Versus Surfactant in Extremely Preterm Infants: The
SUPPORT Trial
* Brett J. Manley
* 20. Target Ranges of Oxygen Saturation in Extremely Preterm Infants:
The SUPPORT Trial
* James I. Hagadorn
* 21. A Trial Comparing Noninvasive Ventilation Strategies in Preterm
Infants
* Brett J. Manley
* 22. High-Flow Nasal Cannulae in Very Preterm Infants after
Extubation: The HIPERSPACE Trial
* Charles Christoph Roehr
* Nutrition
* 23. Randomised Trial of Early Diet in Preterm Babies and Later
Intelligence Quotient
* Michelle Fernandes and Jon Dorling
* 24. Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants
* Susanne Hay and Axel R. Franz
* 25. Promotion of Breastfeeding Intervention Trial: The PROBIT Trial
* Nicholas D. Embleton
* 26. Dextrose Gel for Neonatal Hypoglycemia: The Sugar Babies Trial
* Adel Mohamed, Jyotsna Shah, and Prakesh S. Shah
* 27. Effect of Supplemental Donor Human Milk Compared with Preterm
Formula on Neurodevelopment of Very Low-Birth-Weight Infants at 18
Months: The DOMINO Trial
* Nicholas D. Embleton
* Thermal
* 28. The Influence of the Thermal Environment upon the Survival of
Newly Born Premature Infants
* David Osborn
* 29. Kangaroo Mother Versus Traditional Care for Newborn Infants.
* Srinivas Murki
* Infectious Disease / Immunology
* 30. Palivizumab, A Humanized Respiratory Syncytial Virus Monoclonal
Antibody, Reduces Hospitalization from Respiratory Syncytial Virus
Infection in High-Risk Infants: The IMpact-RSV Trial
* Brian C. King
* 31. Probiotic Effects on Late-Onset Sepsis in Very Preterm Infants:
The ProPrems Trial
* Deena Thomas and M. Jeeva Shankar
* 32. Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease
* Li Ma
* Hematology
* 33. Hemorrhagic Disease of the Newborn
* Anna E. Curley
* 34. Effects of Early Erythropoietin Therapy on the Transfusion
Requirements of Preterm Infants Below 1250 Grams Birth Weight
* Anna E. Curley
* 35. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm
Infants: The TOP Trial
* Axel R. Franz
* 36. A Randomized Trial of Erythropoietin for Neuroprotection in
Preterm Infants: The PENUT Trial
* Nicholas D. Embleton
* 37. Randomized Trial of Platelet-Transfusion Thresholds in Neonates:
The PlaNeT Trial
* Ravi Mangal Patel
* Ophthalmology
* 38. Multicenter Trial of Cryotherapy for Retinopathy of Prematurity,
Preliminary Results: The CRYO-ROP Trial
* James I. Hagadorn
* 39. Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of
Prematurity, Primary Outcomes: The STOP-ROP Trial
* Souvik Mitra
* 40. Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of
Prematurity: The BEAT-ROP Trial
* Brian C. King
* Neurology
* 41. Long-Term Effects of Indomethacin Prophylaxis in
Extremely-Low-Birth-Weight Infants: The TIPP Trial
* Peter W. Fowlie and William McGuire
* 42. Effects of Morphine Analgesia in Ventilated Preterm Neonates,
Primary Outcomes: The NEOPAIN Trial
* Souvik Mitra
* 43. Whole-Body Hypothermia for Neonates with Hypoxic-Ischemic
Encephalopathy
* Anton H. van Kaam and Wes Onland
* 44. Effectiveness of Sucrose Analgesia in Newborns Undergoing Painful
Medical Procedures
* David Osborn
* 45. A Randomized Trial of Prenatal Versus Postnatal Repair of
Myelomeningocele: The MOMS Trial
* Sara DeMauro
* 46. Neurodevelopmental Outcome at Five Years of Age after General
Anaesthesia or Awake-Regional Anaesthesia In Infancy: The GAS Trial
* Sara B. DeMauro
* 47. Levetiracetam Versus Phenobarbital for Neonatal Seizures: The
NEOLEV2 Trial
* Stefan Johansson
* 48. Hypothermia for Moderate or Severe Neonatal Encephalopathy in
Low-Income and Middle-Income Countries: The HELIX Trial
* Srinivas Murki
* Health Services
* 49. Newborn-Care Training and Perinatal Mortality in Developing
Countries: The First Breath Trial
* Danielle E.Y. Ehret
* 50. Effectiveness of Family Integrated Care in Neonatal Intensive
Care Units on Infant and Parent Outcomes
* Evangelia Myttaraki and Chris Gale
* Preface
* Contributors
* Intrapartum Care
* 1. A Controlled Trial of Antepartum Glucocorticoid Treatment for
Prevention of the Respiratory Distress Syndrome in Premature Infants
* Sarah D. McDonald
* 2. Prevention of Early-Onset Neonatal Group B Streptococcal Disease
with Selective Intrapartum Chemoprophylaxis
* Megan J. Turner and Clyde J. Wright
* 3. Reduction of Maternal-Infant Transmission of Human
Immunodeficiency Virus Type 1 with Zidovudine Treatment
* Wes Onland and Anton H. van Kaam
* 4. A Randomized, Controlled Trial of Magnesium Sulfate for the
Prevention of Cerebral Palsy: The BEAM Trial
* Elizabeth Foglia
* Resuscitation
* 5. Resuscitation of Asphyxiated Newborn Infants with Room Air or
Oxygen: The Resair 2 Trial
* Elizabeth Baker and Peter G. Davis
* 6. Delivery Room Management Of The Apparently Vigorous
Meconium-Stained Neonate
* Charles Christoph Roehr
* 7. Randomized Trial of Occlusive Wrap for Heat Loss Prevention in
Preterm Infants: The HeLP Trial
* Anup Katheria
* 8. Association of Umbilical Cord Milking Versus Delayed Umbilical
Cord Clamping with Death or Severe Intraventricular Hemorrhage among
Preterm Infants: The PREMOD2 Trial
* Seh Hyun Kim and Han-Suk Kim
* 9. Effect of Sustained Inflations Versus Intermittent Positive
Pressure Ventilation on Bronchopulmonary Dysplasia or Death among
Extremely Preterm Infants: The SAIL Trial
* Susanne Hay and John Zupancic
* Cardiovascular
* 10. Effects of Indomethacin in Premature Infants with Patent Ductus
Arteriosus
* Souvik Mitra
* 11. Extracorporeal Circulation in Neonatal Respiratory Failure
* Elizabeth Baker and Peter G. Davis
* 12. UK Collaborative Randomised Trial of Neonatal Extracorporeal
Membrane Oxygenation
* Brianna Liberio and Clyde J. Wright
* 13. Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants
with Hypoxic Respiratory Failure: The NINOS Trial
* Dirk Bassler
* Respiratory
* 14. Prevention of Neonatal Respiratory Distress Syndrome by Tracheal
Instillation of Surfactant
* Colm P.F. O'Donnell
* 15. Collaborative Quality Improvement to Promote Evidence Based
Surfactant for Preterm Infants: A Cluster Randomised Trial
* Ashraf Kharrat and Prakesh S. Shah
* 16. Pressure-Regulated Volume Control Ventilation Versus Synchronized
Intermittent Mandatory Ventilation for Very Low-Birth-Weight Infants
* Erik A. Jensen
* 17. Long-Term Effects of Caffeine Therapy for Apnea of Prematurity:
The CAP Trial
* Dirk Bassler
* 18. Outcome at Two Years of Age of Infants from The DART Study: A
Multicenter, International, Randomised, Controlled Trial of Low-Dose
Dexamethasone
* Anton H. van Kaam and Wes Onland
* 19. Early CPAP Versus Surfactant in Extremely Preterm Infants: The
SUPPORT Trial
* Brett J. Manley
* 20. Target Ranges of Oxygen Saturation in Extremely Preterm Infants:
The SUPPORT Trial
* James I. Hagadorn
* 21. A Trial Comparing Noninvasive Ventilation Strategies in Preterm
Infants
* Brett J. Manley
* 22. High-Flow Nasal Cannulae in Very Preterm Infants after
Extubation: The HIPERSPACE Trial
* Charles Christoph Roehr
* Nutrition
* 23. Randomised Trial of Early Diet in Preterm Babies and Later
Intelligence Quotient
* Michelle Fernandes and Jon Dorling
* 24. Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants
* Susanne Hay and Axel R. Franz
* 25. Promotion of Breastfeeding Intervention Trial: The PROBIT Trial
* Nicholas D. Embleton
* 26. Dextrose Gel for Neonatal Hypoglycemia: The Sugar Babies Trial
* Adel Mohamed, Jyotsna Shah, and Prakesh S. Shah
* 27. Effect of Supplemental Donor Human Milk Compared with Preterm
Formula on Neurodevelopment of Very Low-Birth-Weight Infants at 18
Months: The DOMINO Trial
* Nicholas D. Embleton
* Thermal
* 28. The Influence of the Thermal Environment upon the Survival of
Newly Born Premature Infants
* David Osborn
* 29. Kangaroo Mother Versus Traditional Care for Newborn Infants.
* Srinivas Murki
* Infectious Disease / Immunology
* 30. Palivizumab, A Humanized Respiratory Syncytial Virus Monoclonal
Antibody, Reduces Hospitalization from Respiratory Syncytial Virus
Infection in High-Risk Infants: The IMpact-RSV Trial
* Brian C. King
* 31. Probiotic Effects on Late-Onset Sepsis in Very Preterm Infants:
The ProPrems Trial
* Deena Thomas and M. Jeeva Shankar
* 32. Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease
* Li Ma
* Hematology
* 33. Hemorrhagic Disease of the Newborn
* Anna E. Curley
* 34. Effects of Early Erythropoietin Therapy on the Transfusion
Requirements of Preterm Infants Below 1250 Grams Birth Weight
* Anna E. Curley
* 35. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm
Infants: The TOP Trial
* Axel R. Franz
* 36. A Randomized Trial of Erythropoietin for Neuroprotection in
Preterm Infants: The PENUT Trial
* Nicholas D. Embleton
* 37. Randomized Trial of Platelet-Transfusion Thresholds in Neonates:
The PlaNeT Trial
* Ravi Mangal Patel
* Ophthalmology
* 38. Multicenter Trial of Cryotherapy for Retinopathy of Prematurity,
Preliminary Results: The CRYO-ROP Trial
* James I. Hagadorn
* 39. Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of
Prematurity, Primary Outcomes: The STOP-ROP Trial
* Souvik Mitra
* 40. Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of
Prematurity: The BEAT-ROP Trial
* Brian C. King
* Neurology
* 41. Long-Term Effects of Indomethacin Prophylaxis in
Extremely-Low-Birth-Weight Infants: The TIPP Trial
* Peter W. Fowlie and William McGuire
* 42. Effects of Morphine Analgesia in Ventilated Preterm Neonates,
Primary Outcomes: The NEOPAIN Trial
* Souvik Mitra
* 43. Whole-Body Hypothermia for Neonates with Hypoxic-Ischemic
Encephalopathy
* Anton H. van Kaam and Wes Onland
* 44. Effectiveness of Sucrose Analgesia in Newborns Undergoing Painful
Medical Procedures
* David Osborn
* 45. A Randomized Trial of Prenatal Versus Postnatal Repair of
Myelomeningocele: The MOMS Trial
* Sara DeMauro
* 46. Neurodevelopmental Outcome at Five Years of Age after General
Anaesthesia or Awake-Regional Anaesthesia In Infancy: The GAS Trial
* Sara B. DeMauro
* 47. Levetiracetam Versus Phenobarbital for Neonatal Seizures: The
NEOLEV2 Trial
* Stefan Johansson
* 48. Hypothermia for Moderate or Severe Neonatal Encephalopathy in
Low-Income and Middle-Income Countries: The HELIX Trial
* Srinivas Murki
* Health Services
* 49. Newborn-Care Training and Perinatal Mortality in Developing
Countries: The First Breath Trial
* Danielle E.Y. Ehret
* 50. Effectiveness of Family Integrated Care in Neonatal Intensive
Care Units on Infant and Parent Outcomes
* Evangelia Myttaraki and Chris Gale