γδ T Cell Cancer Immunotherapy

Evidence-Based Perspectives for Clinical Translation
Herausgeber: Barisa, Marta

• Gebundenes Buch

Produktbeschreibung

¿¿ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation sets out and critically discusses the current clinical and relevant preclinical ¿¿ T cell immunotherapy landscape. In five chapters, field experts discuss the challenges facing ¿¿ T cell oncoimmunotherapy, propose solutions, and map next steps. Particular attention is given to summarizing our understanding of the complex, translationally relevant human ¿¿ T cell biology, the evidence basis for designing ¿¿ T cell combination trials and data-driven perspectives on what is known-and what isn’t-about ¿¿ T cell therapeutic persistence. Various perspectives are provided on how issues of cytotoxic effector function, functional exhaustion, and cytokine addiction can be mitigated using gene engineering. A chapter is dedicated to the systematic review of all ¿¿ T cell immunotherapy trials to date, and the cell therapy products that were used in these trials. The final chapter discusses allograft persistence-enhancement techniques in the context of ¿¿ T cell therapy, covering lymphodepleting chemotherapy and synthetic stealth engineering. ¿¿ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation gives an updated and comprehensive insight into the current state of ¿¿T cell immunotherapy, which is of interest to existing translational ¿¿ T cell specialists, the proliferating range of academic scientists and commercial scientists entering the field, as well as clinicians who may encounter ¿¿ T cell immunotherapy in the clinic, or are wishing to familiarize themselves with noncanonical lymphocyte immunotherapy.

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Produktdetails

• Breaking Tolerance to Anti-Cancer Cell-Mediated Immunotherapy
• Verlag: Elsevier Science Publishing Co Inc
• Seitenzahl: 208
• Erscheinungstermin: 23. Oktober 2024
• Englisch
• Abmessung: 235mm x 191mm
• Gewicht: 588g
• ISBN-13: 9780443217661
• ISBN-10: 0443217661
• Artikelnr.: 68279439

Inhaltsangabe

1. Exploiting fundamental
T cell immunobiology in cancer immunotherapy: seven steps towards a Great Leap Forwards 2. Examining
T cell receptor (
-TCR) structure and signalling in the context of cellular immunotherapy design 3.
T cell immunotherapy: requirement for combinations? 4. Appraising ???? T Cell Exhaustion and Differentiation in the Context of Synthetic Engineering for Cancer Immunotherapy 5.
T Cells for Cancer Immunotherapy: a 2023 Comprehensive Systematic Review of Clinical Trials 6. Allograft persistence: the next frontier for allogeneic
T cell therapy