This book provides a practical guide to the field of neuromuscular pathology including muscle, peripheral nerve, and skin biopsies with biopsy interpretation. Divided into three parts, the book begins with introductory chapters that review muscle, nerve, and skin biopsy indications and procedures, normal muscle and nerve histology, and common muscle and nerve pathology. The 28 myopathy case chapters in Part 2 and 11 neuropathy case chapters in Part 3 illustrate the clinical and pathological features of many neuromuscular diseases, demonstrate the indications and utilities of biopsies, discuss…mehr
This book provides a practical guide to the field of neuromuscular pathology including muscle, peripheral nerve, and skin biopsies with biopsy interpretation. Divided into three parts, the book begins with introductory chapters that review muscle, nerve, and skin biopsy indications and procedures, normal muscle and nerve histology, and common muscle and nerve pathology. The 28 myopathy case chapters in Part 2 and 11 neuropathy case chapters in Part 3 illustrate the clinical and pathological features of many neuromuscular diseases, demonstrate the indications and utilities of biopsies, discuss clinical and pathological differential diagnosis, update the individual disease management, and summarize pertinent clinical and pathology pearls for each case.
A Case-Based Guide to Neuromuscular Pathology will function as an indispensable reference for neurologists and pathologists looking to understand the utility of muscle, nerve, andskin biopsies. This book will also aid neurology residents, neuromuscular fellows and neuropathology fellows in preparing for questions related to the muscle and nerve pathology in their in-service and board exams.
Lan Zhou, MD, PhD Departments of Neurology and Pathology Boston University Medical Center Boston, MA USA Dennis K. Burns, MD Department of Pathology Neuropathology Section The University of Texas Southwestern Medical Center Dallas, TX USA Chunyu Cai, MD, PhD Department of Pathology The University of Texas Southwestern Medical Center Dallas, TX
Inhaltsangabe
Part I: Introduction to Neuromuscular Pathology Evaluation.-1. Skeletal Muscle Biopsy Evaluation.-2. Peripheral Nerve Biopsy Evaluation.-3. Skin Biopsy with Cutaneous Nerve Fiber Evaluation.-Part II: Myopathy Cases.-4. A 20-year-old man with acute multi-organ failure and rhabdomyolysis.-5. A 45-year-old woman with proximal limb weakness and skin peeling on fingertips.-6. A 75-year-old man with leg and hand weakness.-7. A 53-year-old woman with proximal limb weakness and marked CK elevation.-8. A 61-year-old woman with distal limb and deltoid weakness.-9. A 63-year-old woman with debilitating muscle pain.-10. A 33-year-old woman with pain and swelling in the right calf and persistent fever.-11. A 28-year-old woman with proximal limb weakness and scapular winging.-12. A 52-year-old man with proximal limb weakness and hand stiffness.-13. A 51-year-old woman with long-standing exercise intolerance.-14. A 37-year-old woman with leg weakness.-15. A 25-year-old woman with droopy eyelids and double vision.-16. A 58-year-old man with hypercapnic respiratory failure.-17. A 65-year-old man with asymmetrical leg weakness and foot tingling.-18. A 40-year-old man with muscle pain and fatigue.-19. A 42-year-old woman with progressive limb weakness and breathing difficulty.-20. A 49-year-old man with limb weakness and skin changes.-21. A 54-year-old man with lower limb weakness.-22. A 63-year-old man with progressive limb weakness and slurred speech.-23. A 6-year-old girl with muscle pain and swelling in the thighs.-24. A 4-year-old boy with progressive weakness, difficulty walking and running, and increased falls.-25. A 2-year-old girl with hypotonia since birth and delayed motor and speech development.-26. An 8-year-old boy with delayed motor milestones and proximal leg muscle weakness.-27. A 6-year-old-boy with proximal leg muscle weakness and facial weakness.-28. A 6-week-old boy with neonatal hypotonia and feeding and respiratory difficulties.-29. A 6-year-old boy with respiratory and feeding difficulties at birth, delayed gross motor milestones, and facial and proximal lower limb weakness.-30. A 12-year-old girl with a 2-year history of progressive weakness and difficulties with exercise.-31. A 3-month-old boy with generalized hypotonia, weakness, pneumonia and respiratory failure.-Part III: Neuropathy Cases.-32. A 59-year-old woman with subacute lower limb weakness and painful paresthesia.-33. A 63-year-old man with nausea, vomiting, orthostatic dizziness, and distal limb paresthesia.-34. A 47-year-old woman with progressive numbness and weakness in the limbs.-35. A 65-year-old woman with acute limb weakness and worsening of paresthesia.-36. A 34-year-old man with right hand and left foot numbness.-37. A 64-year-old woman with progressive pain, numbness and weakness in the right lower limb.-38. A 68-year-old man with progressive lower limb numbness and weakness and urinary incontinence.-39. A 53-year-old woman with pain, burning, tingling, and numbnessin the distal limbs.-40. A 40-year-old woman with patchy painful paresthesia.-41. A 39-year-old woman with intermittent bilateral foot and leg pain since childhood.- 42. A 35-year-old man with pain and numbness in the left lateral thigh.
Part I: Introduction to Neuromuscular Pathology Evaluation.-1. Skeletal Muscle Biopsy Evaluation.-2. Peripheral Nerve Biopsy Evaluation.-3. Skin Biopsy with Cutaneous Nerve Fiber Evaluation.-Part II: Myopathy Cases.-4. A 20-year-old man with acute multi-organ failure and rhabdomyolysis.-5. A 45-year-old woman with proximal limb weakness and skin peeling on fingertips.-6. A 75-year-old man with leg and hand weakness.-7. A 53-year-old woman with proximal limb weakness and marked CK elevation.-8. A 61-year-old woman with distal limb and deltoid weakness.-9. A 63-year-old woman with debilitating muscle pain.-10. A 33-year-old woman with pain and swelling in the right calf and persistent fever.-11. A 28-year-old woman with proximal limb weakness and scapular winging.-12. A 52-year-old man with proximal limb weakness and hand stiffness.-13. A 51-year-old woman with long-standing exercise intolerance.-14. A 37-year-old woman with leg weakness.-15. A 25-year-old woman with droopy eyelids and double vision.-16. A 58-year-old man with hypercapnic respiratory failure.-17. A 65-year-old man with asymmetrical leg weakness and foot tingling.-18. A 40-year-old man with muscle pain and fatigue.-19. A 42-year-old woman with progressive limb weakness and breathing difficulty.-20. A 49-year-old man with limb weakness and skin changes.-21. A 54-year-old man with lower limb weakness.-22. A 63-year-old man with progressive limb weakness and slurred speech.-23. A 6-year-old girl with muscle pain and swelling in the thighs.-24. A 4-year-old boy with progressive weakness, difficulty walking and running, and increased falls.-25. A 2-year-old girl with hypotonia since birth and delayed motor and speech development.-26. An 8-year-old boy with delayed motor milestones and proximal leg muscle weakness.-27. A 6-year-old-boy with proximal leg muscle weakness and facial weakness.-28. A 6-week-old boy with neonatal hypotonia and feeding and respiratory difficulties.-29. A 6-year-old boy with respiratory and feeding difficulties at birth, delayed gross motor milestones, and facial and proximal lower limb weakness.-30. A 12-year-old girl with a 2-year history of progressive weakness and difficulties with exercise.-31. A 3-month-old boy with generalized hypotonia, weakness, pneumonia and respiratory failure.-Part III: Neuropathy Cases.-32. A 59-year-old woman with subacute lower limb weakness and painful paresthesia.-33. A 63-year-old man with nausea, vomiting, orthostatic dizziness, and distal limb paresthesia.-34. A 47-year-old woman with progressive numbness and weakness in the limbs.-35. A 65-year-old woman with acute limb weakness and worsening of paresthesia.-36. A 34-year-old man with right hand and left foot numbness.-37. A 64-year-old woman with progressive pain, numbness and weakness in the right lower limb.-38. A 68-year-old man with progressive lower limb numbness and weakness and urinary incontinence.-39. A 53-year-old woman with pain, burning, tingling, and numbnessin the distal limbs.-40. A 40-year-old woman with patchy painful paresthesia.-41. A 39-year-old woman with intermittent bilateral foot and leg pain since childhood.- 42. A 35-year-old man with pain and numbness in the left lateral thigh.
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