A Handbook of Bioanalysis and Drug Metabolism

Herausgeber: Evans, Gary

• Broschiertes Buch

Produktbeschreibung

Taking a unique industrial perspective that reinforces theory and develops valuable analytical and interpretation skills, this book examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. Professionals with extensive experience in drug discovery and development, as well as specialized knowledge of the individual topics, contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics, and drug-drug interactions.

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Produktdetails

• Verlag: Taylor & Francis Ltd (Sales)
• Seitenzahl: 408
• Erscheinungstermin: 25. September 2019
• Englisch
• Abmessung: 251mm x 175mm x 25mm
• Gewicht: 703g
• ISBN-13: 9780367394424
• ISBN-10: 0367394421
• Artikelnr.: 58059098

Autorenporträt

Gary Evans

Inhaltsangabe

The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past,
Present and Future. The Importance of the Physiochemical Properties of
Drugs to Drug Metabolism. Sample Preparation. High Performance Liquid
Chromatography in Pharmaceutical Bioanalysis. Quantitative Mass
Spectronomy. Immunoassay in Bioanalysis. Phase I Metabolism. Phase II
Enzymes. In vitro Techniques for Investigating Metabolism. Drug-Drug
Interactions: an in vitro Approach. Clinical Impact of Drug Interactions.
Preclinical Pharmacokinetics. Pharmacokinetic / Pharmacodynamic Modeling in
Preclinical Drug Discovery. Toxicokinetics. Protein Binding in Plasma: A
Case History of a Highly Protein Bound Drug. Metabolite Identification by
Spectroscopy. Whole Body Autoradiography. Radiolabeled Studies in Man.
Molecular Biology.