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Frontmatter -- Contents -- Opening remarks / Hannse, H. -- Prologue / Greenblatt, R. B. -- 1. Physiology and pathophysiology of the perimenopausal years -- Some aspects of oogenesis, follicular growth, and endocrine involution / Nocke, W. -- The climacteric syndrome / Schneider, H. P. G. -- Skin and the menopause / Brincat, M. -- Osteoporosis: occurrence and diagnosis / Lindsay, R. -- Lipids, hormonal status and the cardiovascular system in the postmenopause / Tikkanen, M. J. / Nikkila, E. A. / Kuusi, T. -- Psychosocial aspects in the perimenopause / Wenderlein, J. M. -- The bladder in the menopausal woman / Versi, E. -- Discussion -- 2. Management of the climacteric patient -- 2.1. General aspects -- The influence of nutrition and exercise / Notelovitz, M. -- Non-hormonal medication / Utian, W. H. -- Discussion -- 2.2. Hormonal treatment -- Selection of patients - kind and duration of treatment / Studd, J. W. W. / Andersen, H. M. / Montgomery, J. C. -- Routes of estrogen administration / Cardozo, L. -- Sex steroids and lipoproteins / Larsson-Cobn, U. / Wallentin, L. -- Discussion -- 2.3. Risk-benefit evaluation of hormonal therapy -- Prospective study on long term risk of hormone replacement therapy / Hunt, K. / Vessey, M. -- Long-term metabolic effects of estrogen therapy / Husmann, F. -- Hormonal replacement therapy and breast cancer / Gambrell, R. D. -- Prevention of endometrial abnormalities / Whitehead, M. I. -- Estrogen/progestogen as a prophylactic treatment of postmenopausal osteoporosis / Christiansen, C. -- Discussion -- 2.4. Special aspects in premenopausal women -- Management of the premenstrual syndrome / Magos, A. L. / Studd, J. W. W. -- Contraception in premenopausal age / Schwartz, U. -- Discussion -- Closing remarks / Crosignani, P. G. -- Epilogue / Greenblatt, R. B. -- List of contributors -- Backmatter