This book explains The efficiency of using the double markers HCG and fetoprotein (AFP) for early detection of congenital abnormalities as Down s syndrome, neural tube defects (NTDs) and Blighted ovum as well as possibility of pregnancy detection in the first week of gestation. Shows the importance of offering prenatal diagnosis to pregnant women with identified risk factor and tells how this could safe women life.The book also gives a brilliant definition of radio immunoassay (RIA) nuclear medicine in vitro technique. The book provides valuable information to the obstetricians in taking suitable decision at the right time.