Terry P Kenakin

A Pharmacology Primer

Techniques for More Effective and Strategic Drug Discovery

• Broschiertes Buch

Produktbeschreibung

Revised edition of: A pharmacology primer / Terry P. Kenakin. 4th ed. c2014.

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Produktdetails

• Verlag: Elsevier Science
• 5th edition
• Seitenzahl: 488
• Erscheinungstermin: 5. November 2018
• Englisch
• Abmessung: 279mm x 212mm x 24mm
• Gewicht: 1220g
• ISBN-13: 9780128139578
• ISBN-10: 0128139579
• Artikelnr.: 52893115

Autorenporträt

Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

Inhaltsangabe

1. What Is Pharmacology?2. How Different Tissues Process Drug Response 3.
Drug-Receptor Theory4. Pharmacological Assay Formats: Binding5. Agonists:
The Measurement of Affinity and Efficacy in Functional Assays6. Orthosteric
Drug Antagonism7. Allosteric Modulation8. The Optimal Design of
Pharmacological Experiments9. Pharmacokinetics10. Safety Pharmacology11.
The Drug Discovery Process12. Statistics and Experimental Design13.
Selected Pharmacological Methods14. Exercises in Pharmacodynamics and
Pharmacokinetics