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Medical sector is a dynamic domain that requires continuous improvement of its business processes and assistance to the actors involved. This research focuses on the medical treatment process requiring prosthesis implantation. The specificity of such a process is that it makes in connection two lifecycles belonging to medical and engineering domains respectively. This implies several collaborative actions between stakeholders from heterogeneous disciplines. However, several problems of communication and knowledge sharing may occur because of the variety of semantic used and the specific business practices in each domain. This context is interested in the potential of knowledge engineering and product lifecycle management approaches to cope with the above problems. The application of the proposition is demonstrated through an implementation of useful function in the the AUDROS PLM software.