Over the past few decades, world-wide interest in environmental, social and economic preservation has involved researchers in a great challenge to find new approaches to manage the impact of human activities. This challenge has significantly impressed the construction sector, as a considerable educator of its surrounding society. The concept of Sustainability has called for a variety of debates and efforts to develop methodologies and tools in order to manage the human social, environmental and economic impacts during the process of buildings' construction, service-life, and disposal. This book presents the key aspects of sustainable building design, resulted by ten years of research work, conducted by the author, in Practical Factors of Sustainable Design and Decision-making such as Time-Based Architecture, Building Life Cycle Assessment (BLCA), and Regenerative Design (one step further than sustainability).