A Silent Threat: Exploring New Therapies for Abdominal Aortic Aneurysms - Mackil
29,45 €
inkl. MwSt.
Versandkostenfrei*
Versandfertig in 6-10 Tagen
payback
0 °P sammeln
  • Broschiertes Buch

Fibronectin (FN) is a component of the interstitial ECM. It also mediates cell attachment and function [16]. It is a fibril-forming glycoprotein which is structurally a dimer of two identical proteins of 250 kDa covalently attached via disulfide bonds at their C termini. It is ubiquitously expressed in tissues. Different functional motifs on its structure helps fibronectin to interact with GAGs, collagens, fibrin and integrins facilitating matrix organization and cell-matrix interactions [18]. For example, fibronectin serves as a template for proper collagen fibrillogenesis by forming a fibril…mehr

Andere Kunden interessierten sich auch für
Produktbeschreibung
Fibronectin (FN) is a component of the interstitial ECM. It also mediates cell attachment and function [16]. It is a fibril-forming glycoprotein which is structurally a dimer of two identical proteins of 250 kDa covalently attached via disulfide bonds at their C termini. It is ubiquitously expressed in tissues. Different functional motifs on its structure helps fibronectin to interact with GAGs, collagens, fibrin and integrins facilitating matrix organization and cell-matrix interactions [18]. For example, fibronectin serves as a template for proper collagen fibrillogenesis by forming a fibril network engaged by cell surface integrins [16]. Cellular traction force causes FN to be stretched several times over its resting length [18]. As a result of such stretching, cryptic integrin-binding sites within the FN molecule is exposed resulting in pleiotropic changes in cellular behavior [18]. Hence FN acts as an extracellular mechano-regulator in addition to its role in cell migration during development. Studies have also shown the implication of FN in cardiovascular diseases and tumor metastasis
Autorenporträt
Professor Mackil is a renowned researcher with a distinguished career in thin-film science and engineering. His passion lies in unraveling the mysteries of epitaxial film formation, a process where crystalline layers are meticulously built one atom at a time. Professor Mackil's book, The Dance of Growth: Temperature, Diffusion, and Seeding in Epitaxial Film Formation, offers a captivating exploration of the delicate interplay between temperature, diffusion phenomena, and seeding mechanisms that orchestrate the creation of these near-perfect films. Throughout his illustrious career, Professor Mackil has made groundbreaking contributions to the field, particularly in elucidating the role of [mention a specific area of Professor Mackil's research]. His pioneering work has been published in top scientific journals and presented at esteemed conferences worldwide. Driven by a desire to foster scientific literacy, Professor Mackil has penned this book with the aim of illuminating the fascinating world of epitaxial growth for researchers, students, and anyone captivated by the atomic foundations of modern technology.