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Successful endodontic treatment involves accurate diagnosis, good understanding of the biological principles and excellent execution of the treatment. To be able to execute an excellent treatment, it's imperative that the clinician has comprehensive knowledge of the root canal anatomy and the know-how to locate and treat this anatomy. Incomplete debridement and disinfection of root canal space as the most important factor in endodontic treatment failure. Missed canal in the initial treatment as a significant cause of root canal failure.