Acid sphingomyelinase deficiency enhances myelin repair - Chami, Marwan
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In this study, we investigated the role of acid sphingomyelinase in demyelination and myelin repair by inducing acute and chronic demyelination with 5- or 12-week cuprizone treatment, followed by a 2-week cuprizone withdrawal phase to allow myelin repair.Our findings suggest that acid sphingomyelinase plays a significant role in myelin repair, and its inhibition by amitriptyline may constitute a novel therapeutic approach for multiple patients.

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Produktbeschreibung
In this study, we investigated the role of acid sphingomyelinase in demyelination and myelin repair by inducing acute and chronic demyelination with 5- or 12-week cuprizone treatment, followed by a 2-week cuprizone withdrawal phase to allow myelin repair.Our findings suggest that acid sphingomyelinase plays a significant role in myelin repair, and its inhibition by amitriptyline may constitute a novel therapeutic approach for multiple patients.
Autorenporträt
Decided to study Multiple Sclerosis and ultimately find a job where I can make an impact for the benefit of Multiple Sclerosis patients. Rooting from the loss of my mother my curiosity increased towards MS from a young age. Earned a BSc and MSc degree in Neurobiology. And a PhD in Neuroimmunology from the Saarland Medical University,Germany.