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Acne vulgaris remains one of the most common diseases affecting skin. Identification of precipitating factor is important because it will help in targeted treatment. Acne is a common clinical manifestation of hyperandrogenemia. Serum testosterone and sex hormone binding globulin (SHBG) are common androgens associated with acne severity. The available literature regarding the relationship of androgenicity and acne severity is not consistent in its conclusions. Over the last few years, adding anti androgen therapy in conventional acne treatment is a major discussion. This book, therefore, provides a negative association between serum testosterone and SHBG with acne severity. Three separate clinical presentations of acne severity categorised by using Global Acne Assessment Scale are investigated. The analysis should help shed some light on whether to investigate and give anti androgen therapy in the treatment of acne, and should be especially useful to professionals in the field of dermatology, cosmetology, endocrinology, general physicians and post graduate trainers of dermatology,or any one else who may be interested to get general information about acne vulgaris.