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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Acoustic targeted drug delivery (ATDD) is a method that uses ultrasound energy to enhance the transport of molecules into and/or across specific tissues. Generally this class of ultrasound energy falls under the class of therapeutic ultrasound, and ranges in ultrasonic frequencies of 1-20MHz and Sound intensitys of 0-30 watts/cm2 The use of ATDD in conjunction with local drug delivery by injection, topical application and convection enhanced delivery shows promise to significantly enhance the treatment of various diseases in the human body by specifically targeting the drug into the tissue. Focused ultrasound similar to High intensity focused ultrasound, but at much lower powers is applied to tissues in conjunction with the local application of pharmological agent. The ultrasound source (or transducer) is pulsed on and off, and moved in a defined patternto sonicate the tissue of interest. The pulsing of the ultrasound serves two purposes 1.