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Palmoplantar keratodermas are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. They have been classified as either hereditary or acquired and are distinguished from each other on the basis of mode of inheritance, presence of transgrediens, co-morbidities, other symptoms, and extent of epidermal involvement. As the studies on acquired palmoplantar keratoderma is meagre, the present study was carried out to investigate the epidemiology of various diseases causing acquired palmoplantar keratodermas group in the subject population. The present study revealed that this ailment is more prevalent in those involved in moderate to heavy manual work, itching was the most prominent symptom seen followed by pain and psoriasis was the most common disease in this study group. One case of lichenoid drug eruption to carbamazepine was seen in our group. This is an interesting report, probably first of its kind. I acknowlege the support rendered by my professor Dr.S.Ramachandra and assistant professor Dr.Nayeem Sadath Haneef for their constant support and encouragement along with my family members during the course of this study.