Recently, the increase of the pathogens resistant to recent antimicrobial agents has become a health problem About 80% of the rationally proceeding antibiotics are produced by actinomycetes and amongst the most abundant producers are Streptomyces and Micromonospora, In addition, a large number of the antibiotics used in clinical are straight natural products and /or semi synthetic derivatives from natural microorganisms and from their secondary metabolites.
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