Chang-Hwei Chen

Activation and Detoxification Enzymes

Functions and Implications

• Gebundenes Buch

Produktbeschreibung

This book discusses the many advances in the understanding of the functions and implications of activation and detoxification enzymes. This organized, concise overview will meet the needs of those who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology, and chemistry. The book will also be valuable to advanced researchers. The book discusses subjects associated with foreign-compound-metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, activation and detoxification enzymes, metabolic enzyme catalytic properties, reactive metabolic intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary-related enzyme modulators, and structural characteristics of enzyme inducers. This new edition is updated throughout andfeatures completely new chapters on Oxidative and Electrophilic Stresses, Metabolite- Mediated Disease Conditions, and Defense Mechanism: Nrf2-ARE Pathway.

Produktdetails

• Verlag: Springer / Springer Nature Switzerland / Springer, Berlin
• Artikelnr. des Verlages: 978-3-031-55286-1
• 2. Aufl.
• Seitenzahl: 276
• Erscheinungstermin: 14. April 2024
• Englisch
• Abmessung: 241mm x 160mm x 21mm
• Gewicht: 526g
• ISBN-13: 9783031552861
• ISBN-10: 3031552865
• Artikelnr.: 69852802

Autorenporträt

Chang-Hwei Chen, PhD, is a biophysicist at the Institute of Health and the Environment, Professor Emeritus of Department of Biomedical Sciences at the School of Public Health, and Former Adjunct Professor of Physics at the University of Albany, Albany, New York 

Inhaltsangabe

Overview.- Foreign Compounds: Foods, Drugs, Chemicals and Life Styles.- Transport and Excretion of Foreign Compounds.- Metabolic Conversion of Foreign Compounds.- Phase I Activation Enzymes.- Phase II Detoxification Enzymes.- Catalytic Reactions of Activation Enzymes.- Catalytic Reactions of Detoxification Enzymes.- Reactive Intermediates and their Interactions.- Metabolite - Associated Cell Toxicities.- Oxidative Stress and Electrophilic Stress.- Metabolic Enzymes: Polymorphism and Species Differences.- Defense Against Oxidative Stress: Nrf2-ARE Pathway.- Inducibility of Metabolic Enzymes.- Inducers of Metabolic Enzymes.- Diversified Classes of Enzyme Modulators.- Metabolite - Mediated Disease Conditions.- Metabolic Enzyme Induction for Health Benefits.- Diet Effects on Metabolic Enzymes.

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Overview.- Lipophilic Foreign Compounds.- Metabolic Conversion of Lipophilic Compounds.- Phase I Enzymes.- Phase II Enzymes.- Reactive Intermediate Formation.- Biomedical and Biochemical Effects.- Genetic Variations in Metabolizing Enzymes.- Inducibility of Metabolizing Enzymes.- Induction and Inhibition Compounds.- Diets Rich in Enzyme Modulators.- Induction of Enzymes for Health Benefits.- Sources of Foreign Compounds.- Catalytic Reactions of Phase I Enzymes.- Catalytic Reactions of Phase II Enzymes.- Diversified Classes of Enzyme Modulators.- Conclusion.- Index.

Rezensionen

"This book succeeds in delivering a broad overview of the subject with a bias towards food components and the consequences of anutrient intake - certainly an interesting aspect. ... this is satisfactory for those just embarking on a career into the fascinating but complex world of drug and foreign compound metabolism." (Steve Mitchell, International Society for the Study of Xenobiotics-Newsletter, January, 2013)