Acute myelogenous leukemia (AML), is the most common form of leukemia in adults. AML is a deadly form of malignancy, the prognosis for which has not improved in the last two decades. More importantly, it is a malignancy that is seen in older adults, therefore the number of cases is likely to rise as the population ages. Over the past 15 years, genetic mechanisms underlying AML have begun to unfold. Additional research in this area has helped identify key components and characteristics. Consequently, targeted therapy of AML is receiving much attention. It is the hope of researchers that as with…mehr
Acute myelogenous leukemia (AML), is the most common form of leukemia in adults. AML is a deadly form of malignancy, the prognosis for which has not improved in the last two decades. More importantly, it is a malignancy that is seen in older adults, therefore the number of cases is likely to rise as the population ages. Over the past 15 years, genetic mechanisms underlying AML have begun to unfold. Additional research in this area has helped identify key components and characteristics. Consequently, targeted therapy of AML is receiving much attention. It is the hope of researchers that as with chronic myelogenous leukemia (CML), and the drug, Gleevec, a targeted therapy for AML will be discovered.
Artikelnr. des Verlages: 11538592, 978-0-387-69257-9
2010
Seitenzahl: 292
Erscheinungstermin: 18. November 2009
Englisch
Abmessung: 241mm x 160mm x 23mm
Gewicht: 549g
ISBN-13: 9780387692579
ISBN-10: 0387692576
Artikelnr.: 22822917
Herstellerkennzeichnung
Books on Demand GmbH
In de Tarpen 42
22848 Norderstedt
info@bod.de
040 53433511
Autorenporträt
Lalitha Nagarajan is an Associate Professor, Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Inhaltsangabe
The Leukemia Stem Cell.- Epigenetic Mechanisms in AML - A Target for Therapy.- Chromosomal Translocations in AML: Detection and Prognostic Significance.- Chromosomal Deletions in AML.- Genes Predictive of Outcome and Novel Molecular Classification Schemes in Adult Acute Myeloid Leukemia.- Receptor Tyrosine Kinase Alterations in AML - Biology and Therapy.- Lineage-Specific Transcription Factor Aberrations in AML.- Proleukemic RUNX1 and CBF? Mutations in the Pathogenesis of Acute Leukemia.- Acute Myeloid Leukemia with Mutated Nucleophosmin (NPM1): Molecular, Pathological, and Clinical Features.- MicroRNAs: New Players in AML Pathogenesis.- Murine Models of Human Acute Myeloid Leukemia.- Apoptosis in Leukemias: Regulation and Therapeutic Targeting.- Acute Promyelocytic Leukemia: A Paradigm for Differentiation Therapy.- Immunotherapy of AML.- Therapy of Acute Myelogenous Leukemia in Adults.
The Leukemia Stem Cell.- Epigenetic Mechanisms in AML - A Target for Therapy.- Chromosomal Translocations in AML: Detection and Prognostic Significance.- Chromosomal Deletions in AML.- Genes Predictive of Outcome and Novel Molecular Classification Schemes in Adult Acute Myeloid Leukemia.- Receptor Tyrosine Kinase Alterations in AML - Biology and Therapy.- Lineage-Specific Transcription Factor Aberrations in AML.- Proleukemic RUNX1 and CBF? Mutations in the Pathogenesis of Acute Leukemia.- Acute Myeloid Leukemia with Mutated Nucleophosmin (NPM1): Molecular, Pathological, and Clinical Features.- MicroRNAs: New Players in AML Pathogenesis.- Murine Models of Human Acute Myeloid Leukemia.- Apoptosis in Leukemias: Regulation and Therapeutic Targeting.- Acute Promyelocytic Leukemia: A Paradigm for Differentiation Therapy.- Immunotherapy of AML.- Therapy of Acute Myelogenous Leukemia in Adults.
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