Mark Chang (Strategic Statistical Consulting)

Adaptive Design Theory and Implementation Using SAS and R

• Broschiertes Buch

Produktbeschreibung

Covering even more adaptive designs, this second edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials. It includes 12 new chapters, more analytical methods, 20 new SAS macros and R functions, and enhanced end-of-chapter problems that give readers hands-on practice addressing issues encountered in designing real-life adaptive trials. The book compares various methods using SAS and R simulations and explains how to analyze data in adaptive trials.

Produktdetails

• Chapman & Hall/CRC Biostatistics Series
• Verlag: Taylor & Francis Ltd
• 2 New edition
• Seitenzahl: 706
• Erscheinungstermin: 14. Oktober 2016
• Englisch
• Abmessung: 235mm x 156mm x 36mm
• Gewicht: 1000g
• ISBN-13: 9781138034235
• ISBN-10: 1138034231
• Artikelnr.: 51761906

Autorenporträt

Chang, Mark

Inhaltsangabe

Introduction. Classic Design. Theory of Hypothesis
Based Adaptive Design. Method with Direct Combination of P
Values. Method with Inverse
Normal P
Values. Adaptive Non
Inferiority Design with Paired Binary Data. Trial Design and Analysis with Incomplete Paired Data. Implementation of N
Stage Adaptive Designs. Conditional Error Function Method and Conditional Power. Recursive Adaptive Design. Unblinded Sample
Size Re
Estimation Design. Blinded Sample Size Re
Estimation. Adaptive Design with Co
Primary Endpoint. Multiple
Endpoint Adaptive Design. Pick
the
Winners Design. The Add
Arms Design for Unimodal Response. Biomarker
Adaptive Design. Biomarker
Informed Adaptive Design. Survival Modeling and Adaptive Treatment Switching. Response
Adaptive Allocation Design. Bayecian Adaptive Dose Finding Design. Bayesian Phase I
II Adaptive Design. Adaptive Design for Biosimilarity Trial. Multi
Regional Adaptive Trial Design. Bayesian Adaptive Design. Planning, Execution, Analysis, and Reporting. Data Analysis of Adaptive Design. Debates in Adaptive Designs. SAS Adaptive Design Modules: SEQDESIGN Procedure. Appendices. Bibliography. Index.