The objective of this book is to optimize network throughput and fairness, and enhance bandwidth utilization in wireless mobile multi-hop relay (MMR) networks. To enhance bandwidth utilization, we propose an adaptive OFDMA frame structure which is used by the base station and the non-transparent relay stations. To optimize throughput and fairness, we develop an adaptive OFDMA allocation algorithm by using the proposed adaptive OFDMA frame. The effectiveness of the proposed schemes has been verified by numeric simulations.