Myron K. Jacobson / Elaine L. Jacobson (eds.)

ADP-RIBOSE TRANSFER REACTIONS

Herausgegeben von Jacobson, Myron K.; Jacobson, Elaine L.

• Gebundenes Buch

Produktbeschreibung

Current interest in NAD (Nicotinamide adenine dinucleotide) in biological systems focuses on its role in ADP-ribose transfer reactions. These appear to be fundamentally involved in the regulation of many physiological processes. The contributions in this monograph thus represent the range of research in the very active investigation of niacin metabolism. The major topics covered are: ??? - Enzymology of ADP-Ribosylation - ADP-Ribosylation and Chromatin Function - Carcinogenesis and Differentiation - NAD Metabolism and Chemotherapy - ADP-Ribosylation and Signal Transduction - Molecular Genetic Approaches to ADP-Ribosylation

Produktdetails

• Verlag: Springer, Berlin
• 1989.
• Seitenzahl: 527
• Erscheinungstermin: September 1989
• Englisch
• Abmessung: 242mm x 162mm x 31mm
• Gewicht: 1060g
• ISBN-13: 9780387970875
• ISBN-10: 0387970878
• Artikelnr.: 24503050

Inhaltsangabe

One: Enzymology of ADP-Ribosylation.- Amino Acid-Specific ADP-Ribosylation: Purification and Properties of an Erythrocyte ADP-Ribosylarginine Hydrolase.- ADP-Ribosyltransferase and Endogenous Acceptor Proteins in Animal Muscle Tissues: ADP-Ribosylation of Ca2+-Dependent ATPase in Rabbit Skeletal Muscle Sarcoplasmic Reticulum and the Effect of Basic Peptides.- Endogenous ADP-Ribosylation of Proteins at Cysteine Residues.- Reversible ADP-Ribosylation of Dinitrogenase Reductase from Rhodospirillum rubrum Regulates the Activity of the Enzyme In Vivo and In Vitro.- Phospho ADP-Ribosylation and Phospho Adenylylation of Proteins.- ADP-Ribosyl Transferase of Mitochondria and of Ribonucleoprotein Particles Containing Silent Messenger RNA.- In Vitro Evidence for Poly(ADP-Ribosyl)ation of DNA Polymerase ?- Primase and Phosphorylation of Poly(ADP-Ribose) Synthetase by Protein Kinase C.- Poly(ADP-Ribose) Glycohydrolase and ADP-Ribosyl Group Turnover.- In Vitro ADP-Ribosylation Utilizing 2 Deoxy-NAD+ as a Substrate.- Reconstitution of an In Vitro Poly(ADP-Ribose) Turnover System.- Effect of Selected Octadeoxyribonucleotides and 6-Amino-1,2 Benzopyroneon Poly(ADP Ribose) Transferase Activity.- Two Tests of the Direction of Elongation of Poly (ADP-ribose): Residues are Added at the Polymerase-Proximal Terminus.- Biosynthesis and Degradation of Poly(ADP-Ribose) Synthetase.- Monoclonal Antibodies Against Poly(ADP-Ribose) Polymerase: Epitope Mapping, Inhibition of Activity and Interspecies Immunoreactivity.- Poly(ADP-Ribose) Polymerase: Determination of Content From TCA-Precipitated Cells, Existence of Species-Specific Isoforms and Changes During the Growth Cycle.- ADP-Ribosylation in Mitochondria: Enzymatic and Non Enzymatic Reactions.- Localization of the Zinc-Binding Sites in the DNA-Binding Domain of the Bovine Poly(ADP-Ribose) Polymerase.- Heterogeneity of Polyclonal Antisera to ADP-Ribose and Their Use as Probes for ADP-Ribosylation in Human Tumor Cells.- ADP-Ribosylating Activity in Sulfolobus solfataricus.- Alteration of Poly(ADP-Ribose) Metabolism By Ethanol: Kinetic Mechanism of Action.- The Effect of Benzamides on the Activity of Nuclear ADP-Ribosyl Transferase and the Accumulation of Poly(ADP-Ribose) In Vivo.- Carba-Nicotinamide Adenine Dinucleotide: Synthesis and Enzymological Application of a Novel Inhibitor of ADP-Ribosyl Transfer.- Purification and Properties of Two Forms of Poly(ADP-Ribose) Glycohydrolase.- Poly(ADP-Ribosyl)ation in Free Cytoplasmic mRNA-Protein Complexes.- New Inhibitors of Poly(ADP-Ribose) Synthetase.- Monoclonal Antibodies to Human Placental Poly(ADP-Ribose) Synthetase.- Characterization of the Human Autoantibody Response to Poly(ADP-Ribose) Polymerase.- In Vivo Automodification of Poly(ADP-Ribose) Polymerase and DNA Repair.- Two: ADP-Ribosylation and Chromatin Function.- ADP-Ribosylation and Chromatin Function.- Modulation of Chromatin Structure by Poly (ADP-Ribosyl)ation.- Automodified Poly(ADP-Ribose) Synthetase Detected in Rat Liver Cells is Selectively Attached to a Nuclear Matrix-Like Structure.- Studies on the Nuclear Distribution of ADP-Ribose Polymers.- A Proposed Molecular Mechanism of Nucleosome Unfolding. Effect of Poly(ADP-Ribose) on DNA-Histone H4 Interaction.- On the Nature of the Interaction Between Poly(ADP-Ribose) Polymerase and DNA.- Inhibition of ADP-Ribosyl Transferase Activity Blocks the Stable Integration of Transfected DNA into the Mammalian Cell Genome.- Role of Poly(ADP-ribose) Polymerase in Ribosomal RNA Gene Transcription.- ADP-Ribosylation of HeLa Chromosomal and Nuclear Proteins: Response to DNA Damage Caused by Chemical Mutagens.- Poly(ADP-Ribose) Polymerase: DNA Complexes Visualized as Looped Structures by Electron Microscopy.- Poly(ADP-Ribose) May Signal Changing Metabolic Conditions to the Chromatin of Mammalian Cells.- Uncoupling of DNA Excision Repair and Chromatin Rearrangements in Poly(ADP-Ribose)-Depleted Cells.- Highly Sensitive Method for Immunohistochemical Detection