Lyle D. Broemeling

Advanced Bayesian Methods for Medical Test Accuracy

• Gebundenes Buch

Produktbeschreibung

This reference presents advanced techniques for assessing medical test accuracy. After a review of the usual measures, including specificity, sensitivity, positive predictive value, negative predictive value, and the area under the ROC curve, the book expands its scope to cover the more advanced topics of verification bias, diagnostic tests with imperfect gold standards, and medical tests where no gold standard is available. The author offers a practical treatment by including R and WinBugs code in the examples and by employing the Bayesian approach throughout the text. He also provides practical problems at the end of each chapter.

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Useful in many areas of medicine and biology, Bayesian methods are particularly attractive tools for the design of clinical trials and diagnostic tests, which are based on established information, usually from related previous studies. Advanced Bayesian Methods for Medical Test Accuracy begins with a review of the usual measures such as specificity, sensitivity, positive and negative predictive value, and the area under the ROC curve. Then the scope expands to cover the more advanced topics of verification bias, diagnostic tests with imperfect gold standards, and those for which no gold standard is available. Promoting accuracy and efficiency of clinical trials, tests, and the diagnostic process, this book: Enables the user to efficiently apply prior information via a WinBUGS package Presents many ideas for the first time and goes far beyond the two standard references Integrates reader agreement with different modalities-X-ray, CT Scanners, and more-to study their effect on medical test accuracy Provides practical chapter-end problems Useful for graduate students and consulting statisticians working in the various areas of diagnostic medicine and study design, this practical resource introduces the fundamentals of programming and executing BUGS, giving readers the tools and experience to successfully analyze studies for medical test accuracy.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 488
• Erscheinungstermin: 1. August 2011
• Englisch
• Abmessung: 240mm x 161mm x 31mm
• Gewicht: 892g
• ISBN-13: 9781439838785
• ISBN-10: 143983878X
• Artikelnr.: 32791759

Autorenporträt

Lyle D. Broemeling, Ph.D., is Director of Broemeling and Associates Inc., and is a consulting biostatistician. He has been involved with academic health science centers for about 20 years and has taught and been a consultant at the University of Texas Medical Branch in Galveston, The University of Texas MD Anderson Cancer Center and the University of Texas School of Public Health. His main interest is in developing Bayesian methods for use in medical and biological problems and in authoring textbooks in statistics. His previous books are Bayesian Analysis of Linear Models, Econometrics and Structural Change(written with Hiraki Tsurumi), Bayesian Biostatistics and Diagnostic Medicine, and Bayesian Methods for Agreement.

Inhaltsangabe

Introduction. Medical Tests and Preliminary Information. Preview of the
Book. Fundamentals of Diagnostic Accuracy
Regression and Medical Test Accuracy. Agreement and Test Accuracy.
Estimating Test Accuracy with an Imperfect Reference Standard. Verification
Bias and Test Accuracy. Test Accuracy and Medical Practice. Accuracy of
Combined Tests. Bayesian Methods for Meta-Analysis. Appendix: Introduction
to WinBUGS.