The success of endodontic treatment depends on eradication of microbes from the root canal system and prevention of reinfection.The triad of biomechanical preparation,chemotherapeutic sterilization and three-dimensional obturation is the hallmark of endodontic success.The purpose of this book is to provide a review of the variables that are fundamental to the most sophisticated irrigation protocol available in order to achieve the highest standards of success and excellence now possible in endodontics.