Advanced Therapy for Hepatitis C

Herausgegeben von McCaughan, Geoffrey W.; McHutchinson, John; Pawlotsky, Jean-Michel

• Gebundenes Buch

Produktbeschreibung

According to the WHO, 170 million people, or 3% of the world's population, are infected with Hepatitis C and at risk of developing liver cirrhosis and/or liver cancer. 3-4 million people each year are newly diagnosed carriers of the virus.

Advanced Therapy for Hepatitis C Infection provides you with expert guidance from the world's leading hepatologists on the very latest treatment options for patients with the HCV virus. Focusing mainly on the efficacy and clinical use of antiviral therapies, key topics include:
Treatment of recurrent hepatitis C following liver transplantation
Antivirals in Cirrhosis and Portal Hypertension
HIV and Hepatitis C co-infection
Cytopenias: how they limit therapy and potential correction
The problem of insulin resistance and its effect on therapy
Antivirals in Acute Hepatitis C

In addition, it fully covers the foundations for understanding antiviral therapies in HCV, such as the complex pharmacology and mechanisms of antiviral drugs. Finally, a chapter on New Horizons: Interleukin 28 and direct-acting antiviral therapy for HCV, offers you a glimpse into the future possibilities for HCV therapy.

Edited by a team of outstanding international reputation, Advanced Therapy for Hepatitis C Infection is an essential tool for all hepatologists and gastroenterologists involved in the management of patients with Hepatitis C.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 232
• Erscheinungstermin: 27. Dezember 2011
• Englisch
• Abmessung: 249mm x 191mm x 18mm
• Gewicht: 700g
• ISBN-13: 9781405187459
• ISBN-10: 140518745X
• Artikelnr.: 34159550

Autorenporträt

Professor Geoff McCaughan is Director of the AW Morrow Liver Centre and Physician in Charge at the Australian National Liver Transplant Unit. John McHutchison is a professor of medicine at Duke University Medical Center, and since 2002, Director of the DCRI's Gastroenterology and Hepatology Research division.

Inhaltsangabe

Contributors
vii Preface
xi Section I Foundations for Understanding Antiviral Therapies in HCV 1 HCV Replication
3 Michael R. Beard 2 Hepatitis C Virus Genotypes
12 Scott A. Read and Mark W. Douglas 3 Immune Responses to HCV: Implications for Therapy
17 David G. Bowen 4 Mechanisms of Action of Antiviral Drugs: The Interferons
25 Edmund Tse and Michael R. Beard 5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs
36 Fred Poordad and Grace M. Chee 6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors
43 Lotte Coelmont
Leen Delang
Mathy Froeyen
Piet Herdewijn and Johan Neyts 7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors
53 Laurent Chatel-Chaix
Martin Baril and Daniel Lamarre 8 Measuring Antiviral Responses
60 Jean-Michel Pawlotsky and Stephane Chevaliez Section II Efficacy and Clinical Use of Antiviral Therapies 9 Genotype 1: Standard Treatment
67 Rebekah G. Gross and Ira M. Jacobson 10 Individually Tailored Treatment Strategies in Treatment-näive Chronic Hepatitis C Genotype 1 Patients
74 Johannes Wiegand and Thomas Berg 11 Genotype 1 Relapsers and Non-responders
84 Salvatore Petta and Antonio Crax`i 12 Standard Therapy for Genotypes 2/3
90 Kenneth Yan and Amany Zekry 13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3
97 Alessandra Mangia
Leonardo Mottola and Angelo Andriulli 14 Genotypes 2 and 3 Relapse and Non-response
104 Stella Mart¿inez
Jose Maria Sanchez-Tapias and Xavier Forns 15 Hepatitis C Genotype 4 Therapy: Progress and Challenges
113 Sanaa M. Kamal 16 Antivirals in Acute Hepatitis C
127 Heiner Wedemeyer 17 Antivirals in Cirrhosis and Portal Hypertension
132 Diarmuid S. Manning and Nezam H. Afdhal 18 Treatment of Recurrent Hepatitis C Following Liver Transplantation
140 Ed Gane 19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations
150 Benjamin Terrier and Patrice Cacoub 20 Cytopenias: How they Limit Therapy and Potential Correction
160 Mitchell L. Shiffman 21 The Problem of Insulin Resistance and its Effect on Therapy
169 Venessa Pattullo and Jacob George 22 HIV and Hepatitis C Co-infection
177 Gail V. Matthews and Gregory J. Dore 23 HCV and Racial Differences
185 Andrew J. Muir 24 HCV and the Pediatric Population
190 Kathleen B. Schwarz 25 New Horizons: IL28
Direct-acting Antiviral Therapy for HCV
196 Alexander J. Thompson
John G. McHutchison and Geoffrey W. McCaughan Index
215