Advanced Wound Repair Therapies

Herausgegeben:Farrar, David

• Gebundenes Buch

Produktbeschreibung

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.

Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.

With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.

Produktdetails

• Woodhead Publishing Series in Biomaterials
• Verlag: Elsevier Science & Technology / Woodhead Publishing
• Artikelnr. des Verlages: C2013-0-17336-9
• Englisch
• Abmessung: 233mm x 155mm x 234mm
• Gewicht: 1170g
• ISBN-13: 9781845697006
• Artikelnr.: 33670046

Autorenporträt

David Farrar is Science Manager for Biomaterials at the Smith and Nephew Research Centre, York, UK

Inhaltsangabe

Part 1 Introduction to chronic wounds: Introduction to wound healing
Dysfunctional wound healing in chronic wounds
The role of micro-organisms and biofilms in dysfunctional wound healing
Scarring and scarless wound healing
Monitoring wound colour and dimensions. Part 2 Biomaterial therapies for chronic wounds: Functional requirements of wound repair biomaterials
Tissue-biomaterial interaction
Repair and regeneration with biomaterial
Spray on wound care
Use of adhesives in wound healing
Assessing the effectiveness of antimicrobial wound dressings. Part 3 Molecular therapies for chronic wounds: Drug delivery dressings
Molecular and/or gene therapies for wound repair
Antimicrobial Dressings. Part 4 Biologically-derived and cell-based therapies for chronic wounds: Engineered tissues for wound repair
Commercialisation of engineered tissue products
Stem-cell therapies. Part 5 Physical stimulation therapies for chronic wounds: Electrical stimulation for wound healing
Therapeutic improvement of scarring
Therapies with emerging evidence of efficacy.

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Contributor contact details

Introduction

Part I: Introduction to chronic wounds

Chapter 1: Dysfunctional wound healing in chronic wounds

Abstract:

1.1 Normal skin wound healing

1.2 Ageing skin and the onset of chronic, dysfunctional wound healing

1.3 Dysfunctional healing of chronic skin wounds

1.4 Conclusions

1.5 Acknowledgements

Chapter 2: The role of micro-organisms and biofilms in dysfunctional wound healing

Abstract:

2.1 Introduction

2.2 Microbiology and biofilms: not mutually exclusive

2.3 Biofilms and the interactive cooperative community

2.4 Biofilms in chronic wounds

2.5 Biofilms as therapeutic or restorative microbiology/modeling

2.6 Conclusion

Chapter 3: Scarring and scarless wound healing

Abstract:

3.1 Introduction

3.2 Wound healing process

3.3 Fibroproliferative scarring

3.4 Scarless fetal wound healing

3.5 Adult versus fetal wound healing

3.6 Treatment options for scars

3.7 Future trends

3.8 Conclusions

Chapter 4: The discovery and development of new therapeutic treatments for the improvement of scarring

Abstract:

4.1 Introduction

4.2 Scar-free and scar-forming healing

4.3 In vitro and in vivo models to investigate the mechanisms of scarring and evaluate potential treatments

4.4 Translation from pre-clinical studies to clinical efficacy

4.5 Understanding the mechanisms of action of prophylactic scar improvement therapies

4.6 Conclusions

Chapter 5: Monitoring chronic wounds and determining treatment

Abstract:

5.1 Introduction

5.2 Wound size measurements

5.3 Wound colour measurements

5.4 Background material

Part II: Biomaterial therapies for chronic wounds

Chapter 6: Functional requirements of wound repair biomaterials

Abstract:

6.1 Introduction

6.2 Wound pain and dressing materials

6.3 Exudate management

6.4 Prevention and control of infection

6.5 Odour management

6.6 Future trends

6.7 Sources of further information and advice

Chapter 7: Tissue-biomaterial interactions

Abstract:

7.1 Introduction: definitions

7.2 Overview of tissue-biomaterial interactions

7.3 Interactions at the biomaterial surface

7.4 Tissue response to biomaterial

7.5 Conclusion

Chapter 8: Polymeric materials for chronic wound and burn dressings

Abstract:

8.1 Introduction

8.2 Advanced moisture-retentive wound dressings

8.3 Polymeric materials in moist wound healing dressings

8.4 Infection control by polymeric wound dressings

8.5 Conclusion

8.6 Future trends

8.7 Acknowledgements

Chapter 9: Dry wound healing concept using spray-on dressings for chronic wounds

Abstract:

9.1 Introduction

9.2 The key properties of an ideal wound dressing

9.3 Using protein-based spray-on dressings in practice

9.4 Case studies

9.5 Conclusions

Chapter 10: Assessing the effectiveness of antimicrobial wound dressings in vitro

Abstract:

10.1 Introduction

10.2 Log reduction testing

10.3 Zone of inhibition (ZOI)

10.4 Bacterial barrier testing

10.5 Other considerations

10.6 Sources of further information and advice

Chapter 11: Adhesives and interfacial phenomena in wound healing

Abstract:

11.1 Principles of adhesion, adhesivity and interfacial behaviour

11.2 Bioadhesion: principles of adhesion applied to wound healing

11.3 Adhesives in wound healing: materials overview

11.4 Surgical adhesives and tissue sealants: structure and properties

11.5 Conclusions

Chapter 12: Wound healing studies and interfacial phenomena: use and relevance of the corneal model

Rezensionen

"... comprises a nice overview of various kinds of therapies and a sufficiently extensive discussion of important (future) materials and treatments. This without neglecting the basics." --Biomat.net, April 2013

"The book comprises a nice overview of various kinds of therapies and a sufficiently extensive discussion of important (future) materials and treatments." --Birgit Stubbe, Biomaterials Network