The most recent pneumonia outbreak caused by a novel coronavirus (COVID- 19) in China is posing a great threat and declared a global public health emergency. The new type of coronavirus was identified as SARS-CoV-2 or known as novel coronavirus (nCov-2019). This virus has the ability to exploits the host cell by making an entry to host body in order to replicating itself. COVID-19 is mainly transmitted via aerosols and droplets that come from the infectee when sneezing or coughing. These droplets can survive on the inanimate surface even in air (aerosol) and transmitted the virus to human. Information regarding coronaviruses transmissibility to hand by contaminated surfaces not identified yet. This book aims to shed a light on the antiseptic-disinfection systems utilizing the Internet of Things (IoT) technology in managing the impact of COVID-19 Pandemic. This book also provides details about the range of the antiseptics-disinfectants and denaturation that have been used in this operation. Moreover, it underlines the tremendous potential of these techniques and future trends for future researches.