The World Congress of In Vitro Fertilization and Alternate Assisted Reproduction, held in Jerusalem, Israel, 2-7 April, 1989, was the sixth in the sequence of these Congresses, but was the first to emphasize the major importance and the place of assisted reproductive technologies in the treatment of infertility. The eternal City of Jerusalem witnessed the gathering of more than 1500 participants from allover the world who shared and exchanged knowledge and up-to-date experience in this ever-evolving field. The high quality scientific contributions to the Congress culminated in the publication…mehr
The World Congress of In Vitro Fertilization and Alternate Assisted Reproduction, held in Jerusalem, Israel, 2-7 April, 1989, was the sixth in the sequence of these Congresses, but was the first to emphasize the major importance and the place of assisted reproductive technologies in the treatment of infertility. The eternal City of Jerusalem witnessed the gathering of more than 1500 participants from allover the world who shared and exchanged knowledge and up-to-date experience in this ever-evolving field. The high quality scientific contributions to the Congress culminated in the publication of this Proceedings. It embraces all-important aspects in the field of in vitro fertilization and alternate assisted reproduction. Papers on controversies and diversities of methods to stimulate the ovaries, imaging techniques, basic research and state-of-the-art papers on ovarian physiology, the role of GnRH and its analog, clinical aspects of IVF treatment and cryopreservation, up-to-date techniques in assisted reproductive technologies that are quickly developing in conjunction with IVF, were included. When should IVF be preferable to surgery? What are the ex pected up-to-date world results and what are the psychological, moral, ethical and religious implications? These are all the concerns of the treating team and are addressed here. Male factor infertility remains a frustrating problem, but advances in the understanding of sperm-egg interaction, sperm evaluation and preparation are reported. Micromanipulation emerges as a possible alternative to bring some relief to this problem, but it also promises to be central in promoting the field of prenatal genetic analysis.
Joseph G. Schenker, Hebrew University, Hadassah Hospital, Jerusalem, Israel.
Inhaltsangabe
1. Controversies in Induction of Ovulation.- Is There a Best Stimulation Protocol?.- Limitations in the Use of Combined Gonadotropin Releasing Hormone Analog and Human Menopausal Gonadotropin for In Vitro Fertilization.- The Combined Pituitary Suppression/Ovarian Stimulation Therapy: Myths and Realities.- Past, Present and Future of Gonadotropins.- 2. Aspects of Ovarian Stimulation in Medically Assisted Reproduction.- Physiology of Follicle Development in Stimulated Cycles.- Safe Gonadotropins.- IVF: LH Surge vs HCG.- Experience with GnRH-Agonists in Ovarian Stimulation.- The Association of Ovarian Hyperstimulation and Zygote Intrafallopian Transfer.- 3. Ovarian Physiology.- Control of Follicular Growth during the Primate Menstrual Cycle.- Growth Factor Modulation of Gonadotropin Action on Porcine Granulosa Cells.- Follicular Rupture during Ovulation: Activation of Collagenolysis.- Involvement of Calcium in the Transduction of the Hormonal Signal for Induction of Oocyte Maturation.- Hydration as the Key Event in Mucification of the Rat Cumulus.- Tumor Necrosis Factor (TNF?) and the Endogenous Prostaglandin Inhibitor (PGIn) in Bovine Follicles.- The Role of Tumor Necrosis Factor in Human Granulosa Cells and Early Embryo.- The Ovarian Renin-Angiotensin System and Compartmental Function in the Ovary.- The Physiology of Human Ovarian Prorenin-Angiotensin System.- 4. GnRH and GnRH Analogs: Basic Aspects.- Prolactin as a Possible Modulator of Gonadotropin Action on the Ovary.- Studies on Pharmacokinetics of LHRH Analogues after Different Modes of Administration.- Ovulation and Stress: Pathophysiology.- GnRH Peptides and Corpus Luteum Regulation.- GnRH Antagonists: New Developments for Indications in Reproductive Medicine.- 5. Alternate Assisted Reproduction.- IVF versus GIFT.- Patient Selection for Assisted Procreation.- Ultrasound-guided Catheterization of the Fallopian Tube for the Non-operative Transfer of Gametes and Embryos.- The Intratubal Transfer of Pronucleus and Early Embryonic Stage Embryos.- Tubal Embryo Transfer (TET) for the Treatment of Couples with Oligoasthenospermia.- The Present Perspectives of Direct Intraperitoneal Insemination.- Lessons Learned from IVC (Intra-vaginal Culture).- The Benefits of Tubal Transfer Procedures.- 6. IVF and Microsurgery in Cases if Mechanical Infertility.- Selection Criteria for Microsurgery, GIFT and IVF.- Tubo-tubal Anastomosis versus In Vitro Fertilization in the Management of Iatrogenic Infertility.- Ectopic Pregnancy and the Decision to Undergo IVF/ET.- 7. Clinical Aspects of IVF Treatments.- The Endocrinology of Stimulated Cycles and Influence on Outcome.- The Influence of Age, Uterine Length, Pre-post Egg Retrieval, Plasma Estradiol Drop, and the Number of Cleaved Embryos Transferred to the Uterus - on Outcome Following IVF/ET.- The Timing of Embryo Transfer and Implantation.- Oocyte Quality According to Protocols for Controlled Ovarian Hyperstimulation and Patients' Age.- Luteal Phase and Embryonic Development in GnRH-Agonist/hMG-Cycles for In Vitro Fertilization.- Follicular Phase Gonadotropin-releasing Hormone Agonist and Human Gonadotropins: A Better Alternative for Ovulation Induction in In Vitro Fertilization.- Progesterone/Estradiol Ratios Predict Outcome in In Vitro Fertilization.- The Influence of Endometrial Preparation Protocols on Embryo Implantation in Human Cryopreservation Treatment.- The Replacement of Frozen-thawed Embryos: Natural or Artificial Cycles?.- Improvement of Ovarian Response to Induction of Superovulation with Combined Growth Hormone - Gonadotropin Treatment.- The Permissive Role of Growth Hormone in Ovulation Induction with Human Menopausal Gonadotropin.- Synchronization of Donor and Recipient Cycles in an Egg Donation Program: Fresh Versus Frozen/Thawed Embryo Transfers.- 8. Male Infertility.- Molecular Mechanisms of Mammalian Sperm-Zona Pellucida Interaction: Crosstalk Between Sperm and Egg.- Carbohydrated-mediated Sperm-Egg Interactions in Ma
1. Controversies in Induction of Ovulation.- Is There a Best Stimulation Protocol?.- Limitations in the Use of Combined Gonadotropin Releasing Hormone Analog and Human Menopausal Gonadotropin for In Vitro Fertilization.- The Combined Pituitary Suppression/Ovarian Stimulation Therapy: Myths and Realities.- Past, Present and Future of Gonadotropins.- 2. Aspects of Ovarian Stimulation in Medically Assisted Reproduction.- Physiology of Follicle Development in Stimulated Cycles.- Safe Gonadotropins.- IVF: LH Surge vs HCG.- Experience with GnRH-Agonists in Ovarian Stimulation.- The Association of Ovarian Hyperstimulation and Zygote Intrafallopian Transfer.- 3. Ovarian Physiology.- Control of Follicular Growth during the Primate Menstrual Cycle.- Growth Factor Modulation of Gonadotropin Action on Porcine Granulosa Cells.- Follicular Rupture during Ovulation: Activation of Collagenolysis.- Involvement of Calcium in the Transduction of the Hormonal Signal for Induction of Oocyte Maturation.- Hydration as the Key Event in Mucification of the Rat Cumulus.- Tumor Necrosis Factor (TNF?) and the Endogenous Prostaglandin Inhibitor (PGIn) in Bovine Follicles.- The Role of Tumor Necrosis Factor in Human Granulosa Cells and Early Embryo.- The Ovarian Renin-Angiotensin System and Compartmental Function in the Ovary.- The Physiology of Human Ovarian Prorenin-Angiotensin System.- 4. GnRH and GnRH Analogs: Basic Aspects.- Prolactin as a Possible Modulator of Gonadotropin Action on the Ovary.- Studies on Pharmacokinetics of LHRH Analogues after Different Modes of Administration.- Ovulation and Stress: Pathophysiology.- GnRH Peptides and Corpus Luteum Regulation.- GnRH Antagonists: New Developments for Indications in Reproductive Medicine.- 5. Alternate Assisted Reproduction.- IVF versus GIFT.- Patient Selection for Assisted Procreation.- Ultrasound-guided Catheterization of the Fallopian Tube for the Non-operative Transfer of Gametes and Embryos.- The Intratubal Transfer of Pronucleus and Early Embryonic Stage Embryos.- Tubal Embryo Transfer (TET) for the Treatment of Couples with Oligoasthenospermia.- The Present Perspectives of Direct Intraperitoneal Insemination.- Lessons Learned from IVC (Intra-vaginal Culture).- The Benefits of Tubal Transfer Procedures.- 6. IVF and Microsurgery in Cases if Mechanical Infertility.- Selection Criteria for Microsurgery, GIFT and IVF.- Tubo-tubal Anastomosis versus In Vitro Fertilization in the Management of Iatrogenic Infertility.- Ectopic Pregnancy and the Decision to Undergo IVF/ET.- 7. Clinical Aspects of IVF Treatments.- The Endocrinology of Stimulated Cycles and Influence on Outcome.- The Influence of Age, Uterine Length, Pre-post Egg Retrieval, Plasma Estradiol Drop, and the Number of Cleaved Embryos Transferred to the Uterus - on Outcome Following IVF/ET.- The Timing of Embryo Transfer and Implantation.- Oocyte Quality According to Protocols for Controlled Ovarian Hyperstimulation and Patients' Age.- Luteal Phase and Embryonic Development in GnRH-Agonist/hMG-Cycles for In Vitro Fertilization.- Follicular Phase Gonadotropin-releasing Hormone Agonist and Human Gonadotropins: A Better Alternative for Ovulation Induction in In Vitro Fertilization.- Progesterone/Estradiol Ratios Predict Outcome in In Vitro Fertilization.- The Influence of Endometrial Preparation Protocols on Embryo Implantation in Human Cryopreservation Treatment.- The Replacement of Frozen-thawed Embryos: Natural or Artificial Cycles?.- Improvement of Ovarian Response to Induction of Superovulation with Combined Growth Hormone - Gonadotropin Treatment.- The Permissive Role of Growth Hormone in Ovulation Induction with Human Menopausal Gonadotropin.- Synchronization of Donor and Recipient Cycles in an Egg Donation Program: Fresh Versus Frozen/Thawed Embryo Transfers.- 8. Male Infertility.- Molecular Mechanisms of Mammalian Sperm-Zona Pellucida Interaction: Crosstalk Between Sperm and Egg.- Carbohydrated-mediated Sperm-Egg Interactions in Ma
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