Advances in Cancer Research

Herausgegeben:Fisher, Paul B.; Tew, Kenneth D.

• Gebundenes Buch

Produktbeschreibung

Advances in Cancer Research, Volume 144, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research. Chapters in this new release include Gene-Environment-Microenvironment Interactions in Melanomagenesis, PP2A and the Cell Cycle, Current Progress Defining Calcium Signals as Therapeutic Targets in Cancer Cells, and much more.

Produktdetails

• Advances in Cancer Research Volume 144
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: S0065-230X(19)X0005-6
• Englisch
• Abmessung: 22mm x 152mm x 229mm
• Gewicht: 750g
• ISBN-13: 9780128171554
• Artikelnr.: 56314676

Autorenporträt

Professor & Chairman, Dept of Cell & Molecular Pharmacology John C. West Chair of Cancer Research, Medical University of South Carolina, USA
The Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.

Inhaltsangabe

1. Macroenvironment-gene-microenvironment interactions in ultraviolet radiation-induced melanomagenesisXuan Mo, Sarah Preston and M. Raza Zaidi2. PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancerHolly Fowle, Ziran Zhao and Xavier Graña3. Clinical and translational advances in esophageal squamous cell carcinomaZachary Wilmer Reichenbach, Mary Grace Murray, Reshu Saxena, Daniel Farkas, Erika G. Karassik, Alena Klochkova, Kishan Patel, Caitlin Tice, Timothy M. Hall, Henry P. Parkman, Sarah J. Ward, Marie-Pier Tétreault and Kelly A. Whelan4. MDA-9/Syntenin: An emerging global molecular target regulating cancer invasion and metastasisSwadesh K. Das, Devanand Sarkar, Luni Emdad and Paul B. Fisher5. Expression of costimulatory and inhibitory receptors in FoxP3⁺ regulatory T cells within the tumor microenvironment: Implications for combination immunotherapy approachesAras Toker and Pamela S Ohashi6. Capsaicinoids enhance chemosensitivity to chemotherapeutic drugsJamie R. Friedman, Stephen D. Richbart, Justin C. Merritt, Haley E. Perry, Kathleen C. Brown, Austin T. Akers, Nicholas A. Nolan, Cathryn D. Stevenson, John D. Hurley, Sarah L. Miles, Maria T. Tirona, Monica A. Valentovic and Piyali Dasgupta7. Marine natural products in the discovery and development of potential pancreatic cancer therapeuticsXiaojuan Wang and Mark T. Hamann8. Cancer stem cells in breast and prostate: Fact or fictionSampayo, Rocío G and Bissell, Mina J9. Racial disparities, cancer and response to oxidative stressJie Zhang, Zhi-wei Ye, Danyelle M. Townsend, Chanita Hughes Halbert and Kenneth D. Tew