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This issue of Surgical Clinics of North America focuses on Advances in Colorectal Neoplasia, and is edited by Dr. Sean J. Langenfeld. Articles will include: Colorectal cancer screening; Imaging for colon and rectal cancer; The difficult colorectal polyp; Emergency presentations of colorectal cancer; Advances in laparoscopic colorectal surgery; Robotic colorectal surgery; Local excision of rectal cancer; New strategies in rectal cancer; Hereditary colorectal cancer syndromes; Dysplasia and cancer in inflammatory bowel disease; Atypical colorectal neoplasms; Resection of the primary tumor in stage IV colorectal cancer: when is it necessary?; Cytoreduction and HIPEC for colorectal cancer; Molecular markers for colorectal cancer, and more!