Advances in Enzymology and Related Areas of Molecular Biology, Volume 78

Herausgegeben von Toone, Eric J.; Meister, Alton

• Gebundenes Buch

Produktbeschreibung

Analyzes the latest advances in mechanistic enzymology
Volume 78
Advances in Enzymology and Related Areas of Molecular Biology is a seminal series in the field of biochemistry, offering researchers access to authoritative reviews of the latest discoveries in all areas of enzymology and molecular biology. These landmark volumes date back to 1941, providing an unrivaled view of the historical development of enzymology. The series offers researchers the latest understanding of enzymes, their mechanisms, reactions and evolution, roles in complex biological processes, and their applications in both the laboratory and industry.
Each volume in the series features contributions by leading pioneers and investigators in the field from around the world. All articles are carefully edited to ensure thoroughness, quality, and readability.
Volume 78 focuses on the transglutaminase family of enzymes from the perspective of biochemistry (structure and activity), human disease, and inhibition for therapeutic intervention. The transglutaminases, first described in 1957, are a large, widely distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains.? The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
With its wide range of topics and long historical pedigree, Advances in Enzymology and Related Areas of Molecular Biology can be used not only by students and researchers in molecular biology, biochemistry, and enzymology, but also by any scientist interested in the discovery of an enzyme, its properties, and its applications.

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Produktdetails

• Advances in Enzymology - and Related Areas of Molecular Biology Vol.78
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 568
• Erscheinungstermin: 15. November 2011
• Englisch
• Abmessung: 231mm x 155mm x 36mm
• Gewicht: 930g
• ISBN-13: 9781118014288
• ISBN-10: 1118014286
• Artikelnr.: 33368007

Autorenporträt

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency-Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.

Inhaltsangabe

Contributors vii Preface ix Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1 Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin Griffin Physiopathological Roles of Human Transglutaminase 2 47 Vittorio Gentile Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97 Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe Djian Transglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161 Soo-Youl Kim Transglutaminase 2 At the Crossroads between Cell Death and Survival 197 Mauro Piacentini, Manuela D'Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo Rodolfo Tissue Transglutaminase and Its Role in Human Cancer Progression 247 Bo Li, Richard A. Cerione, and Marc Antonyak Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2
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Mouse 295 Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo Fesus Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347 Zoltan Nemes Transglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385 Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. Chishti Irreversible Inhibitors of Tissue Transglutaminase 415 Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe Pardin Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449 Mar
a A. Pajares and George D. Markham Index 523