Chetan Chitnis, Deepak Gaur

Advances in Malaria Research

Herausgegeben von Chauhan, Viranderv

• Gebundenes Buch

Produktbeschreibung

Thoroughly reviews our current understanding of malarial biology
Explores the subject with insights from post-genomic technologies
Looks broadly at the disease, vectors of infection, and treatment and prevention strategies
A timely publication with chapters written by global researchers leaders

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 600
• Erscheinungstermin: 1. Oktober 2014
• Englisch
• Abmessung: 246mm x 183mm x 28mm
• Gewicht: 1315g
• ISBN-13: 9781118493793
• ISBN-10: 1118493796
• Artikelnr.: 36147463

Autorenporträt

Deepak Gaur, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India. Chetan Chitnis, International Centre for Genetic Engineering and Biotechnology, New Delhi, India; Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France. Virander S. Chauhan is Director for the International Centre for Genetic Engineering and?Biotechnology, New Delhi Component. Dr. Chauhan's research focuses on Malaria vaccine and drug development. Dr. Chauhan has written numerous articles related to the Fields of malarial biology and drug discovery. Dr. Chaudan is also co-editor of Recombinant and Synthetic Vaccines (Springer 1995).

Inhaltsangabe

List of contributors xiii Foreword xvii Preface xix 1 Introduction: An
overview of malaria and Plasmodium 1 Virander S. Chauhan, Chetan E.
Chitnis, and Deepak Gaur History 1 The life cycle of Plasmodium 3 A
significant milestone in malaria research: Adaptation of Plasmodium to
laboratory culture 4 The advent of present-day technologies and their
applications in malaria research 5 Bibliography 6 2 Exoerythrocytic
development of Plasmodium parasites 9 Volker T. Heussler, Annika
Rennenberg, and Rebecca R. Stanway The sporozoite's journey from the skin
to the liver 10 Sporozoite invasion 14 Parasite development 15 Protein
export from the parasite into the host cell 20 Parasite egress 23 The role
of innate immune responses during merosome formation 26 Acknowledgments 27
Bibliography 27 3 Molecular basis of erythrocyte invasion by Plasmodium
merozoites 33 Deepak Gaur, Chetan E. Chitnis, and Virander S. Chauhan The
structure of the merozoite 39 The steps of erythrocyte invasion 41
Redundancy and ligand-receptor interactions that mediate parasite adhesion
during erythrocyte invasion 57 Signaling events during erythrocyte invasion
by malaria parasites 74 Summary and conclusions 75 Bibliography 75 4 The
biology of malaria transmission 87 Robert E. Sinden Purpose 87 History 87
The current research agenda 88 Biology 88 Population dynamics 106
Transmission-blocking interventions 110 Bibliography 114 5 Comparative and
functional genomics of malaria parasites 125 Martine M. Zilversmit,
Sittiporn Pattaradilokrat, and Xin-zhuan Su An Introduction to Plasmodium
genomes 125 Genome structure of malaria parasites 127 From genome sequences
to gene function 133 Summary 139 Acknowledgments 139 Bibliography 139 6
Gene regulation: New insights and possible intervention strategies 149
Artur Scherf, Nicholas A. Malmquist, Rafael M. Martins, Shruthi S. Vembar,
and Jose-Juan Lopez-Rubio Introduction 149 Modes of gene regulation 150
Drug targeting 164 Perspectives 169 Bibliography 171 7 Molecular genetic
approaches to malaria research 179 Brendan Elsworth, Mauro F. Azevedo,
Brendan S. Crabb, and Paul R. Gilson Transfection methods 179 Genetic
approaches for deriving gene function 184 Conditional knockdown of protein
function 187 Protein reporters 190 Conclusions 192 Bibliography 192 8
Transcriptomics and proteomics 197 Archana P. Gupta, Zbynek Bozdech, and
Peter R. Preiser Transcriptional profiling throughout the parasite life
cycle 198 Transcriptional regulation 201 Transcriptional variation 205
Biological insights 208 Proteomics 208 Translational regulation 209
Conclusion 212 Bibliography 212 9 The biochemistry of Plasmodium
falciparum: An updated overview 219 Hagai Ginsburg MPMP 219 Carbohydrates
219 Lipid metabolism 227 Amino acids 240 Nucleotide metabolism 252
Cofactors 256 Redox metabolism 265 Mitochondrial functions 268 Hemoglobin
digestion and hemozoin production 273 Some reflections for the future 276
Bibliography 277 10 Signaling in malaria parasites 291 Pushkar Sharma and
Sudhir Kumar Protein phosphorylation in Plasmodium 291 Calcium-mediated
signaling in Plasmodium 292 Phosphoinositide signaling and trafficking in
malaria parasites 295 Cyclic nucleotide signaling in the malaria parasite
296 Future challenges 300 Bibliography 300 11 Membrane transport proteins
as therapeutic targets in malaria 307 Sanjay A. Desai, Kempaiah Rayavara,
Paresh Sharma, Sayeed K. Syed, Wang Nguitragool, and Praveen Balabaskaran
Nina Host erythrocyte membrane: A shared ion and nutrient channel 308
Parasitophorous vacuolar membrane: Protein export and solute uptake 311
Parasite plasma membrane: Similar to other eukaryotic cells, but different
314 Digestive vacuole: A specialized lysosome-equivalent in the parasite
316 Mitochondrial inner membrane: An unusual ATP synthase with uncertain
function 318 Conclusions 319 Acknowledgments 319 Bibliography 319 12 The
proteolytic repertoire of malaria parasites 325 Puran Singh Sijwali and
Philip J. Rosenthal Aspartic proteases 325 Cysteine proteases 330
Metalloproteases 333 Serine proteases 335 Threonine proteases 338 Roles of
proteases in parasite development 340 Summary and conclusions 343
Acknowledgments 343 Bibliography 343 13 Development of medicines for the
control and elimination of malaria 353 Jeremy N. Burrows and Timothy N. C.
Wells Targets for the development of future medicines for malaria 356 The
process of drug development 359 Advances in drug development made in the
21st century 365 The global pipeline of new medicines for treating malaria
368 Medicines in the broader context of malaria eradication 370 Conclusion
377 Acknowledgments 377 Bibliography 377 14 Antimalarial drug resistance
383 Naman K. Shah and Neena Valecha Background 383 Causes of drug
resistance 386 Detection of drug resistance 390 Managing drug resistance
397 Conclusion 401 Disclosures 401 Bibliography 401 Further reading 407 15
Epidemiology of Plasmodium falciparum malaria 409 Alberto L.
García-Basteiro, Quique Bassat, and Pedro L. Alonso Burden of disease 409
Geographical distribution of the disease 411 Chain of transmission and
infection cycle 413 Malaria endemicity and malaria transmission 415 Malaria
elimination and eradication 423 Bibliography 424 16 Malaria pathogenesis
427 Bronner P. Gonçalves, Michal Fried, and Patrick E. Duffy Malaria
illness 427 Host susceptibility 439 Parasite virulence 444 Conclusions 450
Bibliography 451 17 Host genetics 465 Thomas N. Williams What evidence is
there that the risk of malaria is genetically determined? 465 Identifying
the genes involved 466 Why is genetic resistance important? 467 Genetic
polymorphisms of the red blood cell 468 Hemoglobinopathies 474 G6PD
deficiency 478 Non-red blood cell polymorphisms 479 Concluding remarks 481
Bibliography 481 18 The immune response in mild and severe malaria: Two
sides of the same coin 495 Michael Waisberg, Peter D. Crompton, Louis H.
Miller, and Susan K. Pierce The picture of the acquisition of resistance to
uncomplicated and severe malaria: Framing the questions 495 Searching for
host genes that confer immune resistance to severe malaria 506 SLE
susceptibility and resistance to severe malaria 507 The relationship
between the pathogen environment and susceptibility to severe malaria 510
Summary 511 Acknowledgments 511 Bibliography 512 19 Progress in development
of malaria vaccines 521 Chetan E. Chitnis, Deepak Gaur, and Virander S.
Chauhan Immunity to malaria 521 Life cycle of malaria parasites and points
of intervention with vaccines 522 Pre-erythrocytic stage vaccines 524
Blood-stage vaccines 526 Transmission-blocking vaccines 533 Live attenuated
vaccines for malaria 534 Conclusion 535 Bibliography 535 20 Plasmodium
vivax: Insights on burden and pathobiology 547 Ivo Mueller, Quique Bassat,
Marcus V. G. Lacerda, and Hernando A. del Portillo Burden of Plasmodium
vivax infection and disease 547 Severe Plasmodium vivax malaria 550
Molecular basis of severe disease 552 Concluding remarks and outstanding
research questions 558 Bibliography 558 Index 565