Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity of chemicals and other agents. Permanent mutation in genes and chromosomes can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discussed in Advances in Mutagenesis Research are: 1. The understanding of the molecular mechanisms leading to mutations, and 2. the prevention of a thoughtless introduction of mutagenic agents into the environment.
Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity of chemicals and other agents. Permanent mutation in genes and chromosomes can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discussed in Advances in Mutagenesis Research are: 1. The understanding of the molecular mechanisms leading to mutations, and 2. the prevention of a thoughtless introduction of mutagenic agents into the environment.
Micronucleus Assays.- 1 Major Historical Events in Micronucleus Research.- 2 Characteristics, Origin, and Criteria of Micronuclei.- 3 Assay Systems and Methods for Detection of Micronuclei.- 4 Artifacts and Pitfalls.- 5 Characteristics of the Assay System Affecting Micronucleus Yield.- 6 Advantages and Disadvantages of Micronuclei as Assay System.- 7 Application of Micronuclei in Various Fields of Research.- 8 Future Aspects of Micronucleus Research.- References.- Mechanisms of Thermal Radiosensitization Studied in CHO Cells.- 1 Introduction.- 2 Effect of Heat on Radiosensitivity.- 3 DNA Damage.- 4 Effect of Heat on the Activity of Polymerase ß.- 5 Summary.- References.- Alexandra A. Prokofyeva-Belgovskaya (1903-1984) Her Life and Contribution to Cytogenetics.- 1 Bibliographical Notes.- 2 Studying Animal Chromosome Morphology.- 3 Collaboration with C.B. Bridges and H.J. Muller.- 4 Genes and Chromomeres.- 5 Studying Heterochromatic Regions of Drosophila Chromosomes.- 6 The Chromocenter and the X and Y Chromosomes.- 7 Discovery of Telomeric and Intercalary Heterochromatin.- 8 Discovery of High X-Ray Sensitivity of Heterochromatic Regions.- 9 Position Effect of the Variegated Type and the "Heterocyclicity Hypothesis".- 10 Victim of Lysenko.- 11 Restitution.- 12 Human Chromosome Research.- 13 Family and Friends.- 14 The Leader of Cytogenetics in the USSR.- 15 Place in History.- References.
Micronucleus Assays.- 1 Major Historical Events in Micronucleus Research.- 2 Characteristics, Origin, and Criteria of Micronuclei.- 3 Assay Systems and Methods for Detection of Micronuclei.- 4 Artifacts and Pitfalls.- 5 Characteristics of the Assay System Affecting Micronucleus Yield.- 6 Advantages and Disadvantages of Micronuclei as Assay System.- 7 Application of Micronuclei in Various Fields of Research.- 8 Future Aspects of Micronucleus Research.- References.- Mechanisms of Thermal Radiosensitization Studied in CHO Cells.- 1 Introduction.- 2 Effect of Heat on Radiosensitivity.- 3 DNA Damage.- 4 Effect of Heat on the Activity of Polymerase ß.- 5 Summary.- References.- Alexandra A. Prokofyeva-Belgovskaya (1903-1984) Her Life and Contribution to Cytogenetics.- 1 Bibliographical Notes.- 2 Studying Animal Chromosome Morphology.- 3 Collaboration with C.B. Bridges and H.J. Muller.- 4 Genes and Chromomeres.- 5 Studying Heterochromatic Regions of Drosophila Chromosomes.- 6 The Chromocenter and the X and Y Chromosomes.- 7 Discovery of Telomeric and Intercalary Heterochromatin.- 8 Discovery of High X-Ray Sensitivity of Heterochromatic Regions.- 9 Position Effect of the Variegated Type and the "Heterocyclicity Hypothesis".- 10 Victim of Lysenko.- 11 Restitution.- 12 Human Chromosome Research.- 13 Family and Friends.- 14 The Leader of Cytogenetics in the USSR.- 15 Place in History.- References.
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