B. W. Agranoff, M. H. Aprison

Advances in Neurochemistry

Volume 3

• Broschiertes Buch

Produktbeschreibung

The original premise of the Editors in initiating this series was that there existed a readership ofneurochemists with considerable biochemical back ground who would make use of a series dedicated to both new develop ments and specialized reviews in neurochemistry. Having selected our authors, we have offered them virtually complete freedom to reflect and speculate in a field in which they have achieved prominence. The response to the first two volumes has been rewarding. The present one continues in this tradition. While we have not attempted to publish specialized volumes, the present volume contains two somewhat related chapters (Chapters 4 and 5, on the role of amino acid neurotransmitters). The first three chapters examine three diverse approaches, each of current interest, in neurochemi cal approaches to the molecular bases of neuronal and glial structure. B. W. Agranoff M. H. Aprison vii CONTENTS CHAPTER 1 2',3'-CYCUC NUCLEOTIDE 3'-PHOSPHODIESTERASE NEIL RAYMOND SIMS AND PATRICK ROBERT CARNEGIE 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Assay of CNPase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. Need for Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. Comparison of Assays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Association of CNPase with Myelin . . . . . . . . . . . . . . . . . . . . . . . 7 3. 1. Historical. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 2. Subcellular Fractionation. . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 3. Development. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 4. Mutant Mice . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 5. Use as a Myelin Marker . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 3. 6. Myelin-Related Fractions and Peripheral Nerve Myelin. 11 4. CNPase in Nonmyelin Fractions. . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. Activation and Isolation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 2. Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 5. 3. Solubilization and Fractionation. . . . . . . . . . . . . . . . . . . . . . 15 6. Properties. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 6. 1. Substrate Specificity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4615-8242-7
• Softcover reprint of the original 1st ed. 1978
• Seitenzahl: 320
• Erscheinungstermin: 6. Januar 2012
• Englisch
• Abmessung: 235mm x 155mm x 18mm
• Gewicht: 487g
• ISBN-13: 9781461582427
• ISBN-10: 1461582423
• Artikelnr.: 41320612

Inhaltsangabe

1 2?,3?-Cyclic Nucleotide 3?-Phosphodiesterase.- 1. Introduction.- 2. Assay of CNPase.- 3. Association of CNPase with Myelin.- 4. CNPase in Nonmyelin Fractions.- 5. Activation and Isolation.- 6. Properties.- 7. CNPase in Pathological Conditions.- 8. Conclusions and Speculations.- 9. References.- 2 Immunohistochemistry of Nervous System-Specific Antigens.- 1. Introduction.- 2 Immunofluorescent Markers.- 3. Heavy Metal Markers.- 4. Enzyme Markers.- 5. Multiple Antigen Localization.- 6. Tissue Preparation.- 7. Immunohistologic Controls.- 8. General Immunohistochemical Application.- 9. Nervous System Antigens.- 10. References.- 3 Molecular Composition and Functional Organization of Synaptic Structures.- 1. Introduction.- 2. Preparation of Synaptic Structures.- 3. Characterization of Synaptic Structures.- 4. Functional Organization.- 5. Prospect.- 6. References.- 4 The Multiple Roles of Glutamate and Aspartate in Neural Tissues.- 1. Introduction.- 2. The Putative Neurotransmitter Function.- 3. Glutamate and Aspartate as Constituents of Protein.- 4. The Role in the Regulation and Maintenance of Intracellular Osmotic and Ionic Balance.- 5. The Roles of Glutamate and Aspartate in Nitrogen Metabolism.- 6. The Involvement of Glutamate and Aspartate in Energy Metabolism.- 7. Compounds of Neurochemical Interest Derived from Glutamate and Aspartate.- 8. The Possible Role of Glutamate in Amino Acid Transport.- 9. Future Directions.- 10. References.- 5 Biochemical Aspects of Transmission at Inhibitory Synapses: The Role of Glycine.- 1. Introduction.- 2. The Presynaptic Criterion.- 3. The Criterion of Identity of Action.- 4. The Release Criterion.- 5. Other Neurobiological Supportive Studies.- 6. Metabolic Studies.- 7. Other Experimental Studies.- 8. A Functional Model ofGlycinergic Neurotransmission.- 9. Neurological Significance.- 10. Concluding Remarks.- 11. References.