This book discusses the advances in chemistry and applications of organotin compounds in many potential aspects of research laboratories. This book is based on the following items: overview, synthetic methods, reactions and applications of organotin compounds. Organotin compounds or stannanes are chemical compounds based on tin with hydrocarbon substituents. Organotin chemistry is part of the wider field of organometallic chemistry. The organotin reagents are used in synthetic organic chemistry to get new organic compounds with variety of applications. Tin has many industrial applications and uses such as in manufacture of polyesters, polyurethane foam industry, stabilizers for transformer oils and also, as homogeneous catalysts in the plastics industry. One of the fastest growing fields of application for organotin compounds is based upon their biological properties.The biological effects of organotin compounds on organisms depend on both the nature and the number of the organicgroups bound to the tin cation in the organotin compounds. In recent years new sensitive analytical techniques have been developed for the detection of organotin compounds in various environmental sample.