The study of the knowledge, attitudes and practices of mothers of EPI target children on Adverse Events Post Immunization in the city of KANANGA was conducted in JUNE 2022; this descriptive cross-sectional study was carried out through a prospective survey of women with children in the 0-11 months age group (main age for vaccination against preventable diseases). The main findings were as follows: - 184 women, i.e. 43.6%, said they had received information on MAPI, while 238 women, i.e. 56.4%, said they had not; and in relation to the attitude of mothers of EPI-targeted children towards the onset of adverse events following immunization;- 173 women, i.e. 41%, said they had experienced a few cases of severity in their children, while 249 mothers, i.e. 59%, said they had not;- With regard to practices in the event of post-immunization adverse events, 166 mothers (39.3%) gave painkillers to their children, while 65 mothers (15.4%) took their children back to the health center.