While recognizing the potential of genomics in improving health and the unprecedented advances in genomic science, plus its widely predicted revolutionary prevarication; as we look at these realities, how then can we present and apply this scientific knowledge to our global world? In the same vein, while proffering solutions in some genomic problem domain via culminating a positive evolvement of human genome, where do developing countries (for example Nigeria) stand in this revolutionary emancipation? The author addresses these concerns through excavating its fundaments in this compact manual and rekindles hope as he shares perspectives and infers possibilities, comparably, for advancement.