In den letzten Jahren hat unser Wissen über den menschlichen Alterungsprozeß beträchlich zugenommen. Altersbedingte Erkrankungen und Sterblichkeit sind von Mensch zu Mensch sehr verschieden. Dieses Buch behandelt die individuellen Unterschiede und die Anfälligkeit für altersbedingte Erkrankungen. Spezielle Kapitel widmen sich der altersbedingten Pathologie des Gehirns, altersbedingten Prozessen in den Stammzellen sowie altersbedingten Auswirkungen auf das Immunsystem, das Knochen-, Muskel und kardiovaskuläre Gewebe.
In den letzten Jahren hat unser Wissen über den menschlichen Alterungsprozeß beträchlich zugenommen. Altersbedingte Erkrankungen und Sterblichkeit sind von Mensch zu Mensch sehr verschieden. Dieses Buch behandelt die individuellen Unterschiede und die Anfälligkeit für altersbedingte Erkrankungen. Spezielle Kapitel widmen sich der altersbedingten Pathologie des Gehirns, altersbedingten Prozessen in den Stammzellen sowie altersbedingten Auswirkungen auf das Immunsystem, das Knochen-, Muskel und kardiovaskuläre Gewebe.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Inhaltsangabe
Symposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation, London, 29 February^3 March 2000 Editors: Gregory Bock (Organizer) and Jamie A. Goode This symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project 'A Research Agenda on Ageing for the 21st Century' Thomas B. L. Kirkwood Introduction 1 Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4 Discussion 9 Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? 11 Discussion 20 Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts 26 Discussion 38 General discussion I The role of glial cells in the ageing brain 44 R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O'Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49 Discussion 60 C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66 Discussion 79 Amiela Globerson Haematopoietic stem cell ageing 85 Discussion 96 General discussion II 101 James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105 Discussion 110 Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116 Discussion 125 Rita B. E¡ros Ageing and the immune system 130 Discussion 139 General discussion III 146 Lis Mosekilde Mechanisms of age-related bone loss 150 Discussion 166 Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172 Discussion 196 Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202 Discussion 212 General discussion IV 217 Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221 Discussion 230 D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234 Discussion 243 Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247 Discussion 263 Final discussion 267 Index of contributors 273 Subject index 275
Symposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation, London, 29 February^3 March 2000 Editors: Gregory Bock (Organizer) and Jamie A. Goode This symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project 'A Research Agenda on Ageing for the 21st Century' Thomas B. L. Kirkwood Introduction 1 Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4 Discussion 9 Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? 11 Discussion 20 Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts 26 Discussion 38 General discussion I The role of glial cells in the ageing brain 44 R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O'Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49 Discussion 60 C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66 Discussion 79 Amiela Globerson Haematopoietic stem cell ageing 85 Discussion 96 General discussion II 101 James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105 Discussion 110 Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116 Discussion 125 Rita B. E¡ros Ageing and the immune system 130 Discussion 139 General discussion III 146 Lis Mosekilde Mechanisms of age-related bone loss 150 Discussion 166 Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172 Discussion 196 Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202 Discussion 212 General discussion IV 217 Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221 Discussion 230 D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234 Discussion 243 Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247 Discussion 263 Final discussion 267 Index of contributors 273 Subject index 275
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