Alcohol and other drug use continue to be a major issue on college and university campuses. Few studies have examined alcohol and other drug related issues for a graduate or professional student population. This study examines attitudes, incidents, and consequences of alcohol and other drug use among students enrolled at an academic heath science center. This study incorporated a descriptive research design and utilized the CORE Alcohol and Drug Survey for the collection of data. The data were analyzed using descriptive statistics. Statistically significant findings are reported in relation to perceptions of use, actual use, reasons for use, and consequences for use. Additional findings are shown relative to age, gender, marital status, ethnicity, and academic program. This study identifies the need to investigate alcohol and drug related attitudes, behaviors, and consequences among students studying for professions in health related fields.