To present an overview of the main agents and/or strategies currently available to amplify or stabilize resin-dentin bonding. We contributed to the better understanding of adhesion concepts and mechanisms of resin-dentin bond degradation, showing the current prospects available to solve that problematic. Also, adhesively-bonded restorations may be benefited by the use of some biomolecules, nano-compounds or alternative bonding strategies in order to minimize bond strength degradation.