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In this book we have tested and discussed in the light of national and international research finding the anti mutagenic and anticarcinogenic potential of some natural bioactivators like, vitamin's of B-Complex and C, Carotenoids, Flavonoids, Sulforaphane, curcumin, ellagic acid etc. We have tested these bioactivators abainst genotoxicity induced by Cyclophosphamide, Hydrocortisone, and Aflatoxin B1(Mycotoxin) using in vitro method (Human lymphocyte culture)and in vivo method (in bone marrow cell of Albino mice).