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Amniotic membrane holds significant promise in revolutionizing endodontic treatment. Its unique biological properties make it an ideal candidate for enhancing healing and regeneration in various endodontic procedures. With its anti-inflammatory and immunomodulatory capabilities, amniotic membrane reduces inflammation and promotes tissue repair, crucial in addressing common challenges like periapical lesions and apical periodontitis. Additionally, its antimicrobial properties help prevent infections, ensuring the success of endodontic therapies. Amniotic membrane also serves as a scaffold for tissue regeneration, making it valuable in regenerative endodontics. Moreover, its ease of application and biocompatibility contribute to its appeal, offering a minimally invasive option for patients. Despite being in early stages, amniotic membrane shows promising results, indicating its potential to become a standard component in endodontic practice. Further research and standardization are essential to fully realize its benefits and integrate it effectively into endodontic treatments.