This book constitutes the synthesis of various organic intermediates and drug molecules with their physical and chemical properties and applications. Students will be able to develop skills to synthesize organic and medicinal intermediates and API. This book also includes assay of many drugs as per Indian Pharmacopoeia (IP) which are already available in market. At last, students will get expertise to determine partition co-efficient of compounds. This book will be helpful to students to gather knowledge and skill of organic and medicinal chemistry. This book is designed especially for pharmacy, allied science, and basic science students. It covers all experiments that are required to understand as per PCI syllabus of medicinal chemistry-I for B. Pharm. second year, and diploma courses as well as for B. Sc, M. Sc and B. Tech students. The editors and authors are confident that this book will satisfy the necessity of students, teachers and researchers.