An Illustrated Guide to Cancer Biology offers a comprehensive exploration of the fundamentals of oncological molecular biology and provides valuable insights into topics such as cancer cell migration, chemotherapeutic drug mechanisms, and the roles of RNA in cancer. With 33 chapters covering a wide array of subjects, including the Hanahan and Weinberg hallmarks of cancer, tumor heterogeneity, and hormone-dependent cancer, this guide serves as an indispensable resource for researchers, students, and practicing oncologists in medicine, oncology, and biochemistry alike. This book stands out not…mehr
An Illustrated Guide to Cancer Biology offers a comprehensive exploration of the fundamentals of oncological molecular biology and provides valuable insights into topics such as cancer cell migration, chemotherapeutic drug mechanisms, and the roles of RNA in cancer. With 33 chapters covering a wide array of subjects, including the Hanahan and Weinberg hallmarks of cancer, tumor heterogeneity, and hormone-dependent cancer, this guide serves as an indispensable resource for researchers, students, and practicing oncologists in medicine, oncology, and biochemistry alike. This book stands out not only for its comprehensive coverage of diverse topics but also for its unique approach. With over 400 figures strategically interspersed throughout the text, this book offers readers a visually engaging journey through the intricacies of cancer biology. These illustrations, ranging from molecular pathways to cellular interactions, make navigating topics like chemotherapeutic drug mechanisms and tumor heterogeneity more accessible. Additionally, the inclusion of sections on repurposing drugs, tumor kinetics, and epigenetics further aids in a deep understanding of cancer biology.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Tomas Koltai is Board Certified Specialist in Medical Oncology (1985), PhD in Chemistry (1997) and Master's in Sciences in Molecular Oncology, University of Buenos Aires (2011). He has vast experience on cancer treatment at several positions: staff oncologist, Sanatorio Mater Dei, Argentina (1985-1990); Head of Oncology, Central Hospital of the Centro Gallego de Buenos Aires (1990-2000) and Medical Director, at the same institution (2000-2002); Head of the Department of Chemotherapy, National Social Services for Retirees, Argentina (2002-2014); Head of the Department of Oncology, Social Services of the National Food Workers Union, Argentina (2010-2014) and Medical Director at the same institution (2014-2016). He has authored several seminal publications on cancer and created the new "triple-edged cancer treatment?.
Inhaltsangabe
1. Introduction 2. Basics of oncological molecular biology PART I 3. Basics of oncological molecular biology PART II: JUNK DNA AND CANCER: POSSIBLE ROLE OF TRANSPOSONS. 4. Basics of oncological molecular biology Part 3: THE LABORATORY IN MOLECULAR ONCOLOGY. A SYNOPSIS OF THE MOST IMPORTANT TOOLS 5. Basics of oncological molecular biology PART 4: SOME BASIC DEFINITIONS 6. The Hanahan and Weinberg hallmarks of cancer 7. Biology of metastasis 8. Mitotic errors, mutations and DNA repair 9. Growth factors, their receptors and proliferative pathways 10. Angiogenesis 11. Hypoxia in cancer 12. The Unique Metabolism of Cancer Cells - Part 1: Carbohydrates 13. The Unique Metabolism of Cancer Cells - Part 2: 14. The Unique Metabolism of Cancer Cells - Part 3: 15. The Unique Metabolism of Cancer Cells - Part 4: Iron metabolism in cancer 16. Molecular mechanisms of action of chemotherapeutic drugs 17. ROS and cancer 18. Targeted Cancer Treatments - Part I 19. Targeted Cancer Treatments - Part II: Antibody Drug Conjugates for cancer treatment: present and future 20. Cancer and the immune system - Part I 21. Cancer and the immune system - Part II 22. Cancer and the immune system - Part III: Some caveats about immunology and cancer. A historical and clinical perspective 23. The tumor microenvironment - Part I: Cancer environment and Groucho Marx’s principles 24. The tumor microenvironment - Part II: CELLS IN THE TUMOR MICROENVIRONMENT 25. The tumor microenvironment - Part III: Non-cellular components of the tumor microenvironment 26. The tumor microenvironment - Part IV: Adhesion molecules 27. The tumor microenvironment - Part V: Cytokines 28. The tumor microenvironment - Part VI: Chemokines in the TME 29. Tumor heterogeneity: A different way of looking at cancer 30. Resistance to treatment and multidrug resistance (MDR) 31. Pancreatic cancer: a paradigm of difficulties and drug resistance 32. Cancer cachexia 33. Tumor markers 34. The origins and pathogenesis of cancer 35. Extracellular vesicles: Exosomes and microvesicles in cancer. A message in a bottle. 36. Cancer stem cells 37. Repurposing drugs and nutraceuticals for cancer treatment - PART 1: General Concept 38. Repurposing drugs and nutraceuticals for cancer treatment - PART 2: Repurposable Drugs 39. Repurposing drugs and nutraceuticals for cancer treatment - PART 3 Repurposing Metformin 40. Repurposing drugs and nutraceuticals for cancer treatment - PART 4 Repurposable Nutraceuticals 41. The metabolic control center: a survival hub for normal and cancer cells 42. pH homeostasis and ion channels in cancer 43. Tumor growth and genetic evolution - Part I: Tumor growth and kinetics 44. Protein degradation in cancer - Part 1 45. Protein degradation in cancer - Part II : The unfold protein response (UPR) 46. Cell migration in cancer - Part I: mechanisms of migration and invasion 47. Cell migration in cancer - Part II: Targeting cancer cell migration and invasion 48. Cell migration in cancer - Part III: The "go or grow" hypothesis and some caveats 49. RNA in cancer - Part I: MicroRNAs MiRs or miRNAs 50. RNA in cancer - Part II: Long non-coding RNA (lncRNA) 51. RNA in cancer - Part III: RNA binding proteins (RBPs) 52. Epigenetics and cancer 53. Peroxisome, peroxisome proliferators and peroxisome proliferator-activated receptors in cancer 54. The renin-angiotensin system signaling pathways and cancer: two sides of the same coin 55. Hormone-dependent cancer 56. Chapter 34 Part 1: Cancer and inflammation 57. Chapter 34 part 2: Links between inflammation and cancer 58. Chapter 34 part 3: Caveats about anti-inflammatory drugs and cancer 59. Summary and final words
1. Introduction 2. Basics of oncological molecular biology PART I 3. Basics of oncological molecular biology PART II: JUNK DNA AND CANCER: POSSIBLE ROLE OF TRANSPOSONS. 4. Basics of oncological molecular biology Part 3: THE LABORATORY IN MOLECULAR ONCOLOGY. A SYNOPSIS OF THE MOST IMPORTANT TOOLS 5. Basics of oncological molecular biology PART 4: SOME BASIC DEFINITIONS 6. The Hanahan and Weinberg hallmarks of cancer 7. Biology of metastasis 8. Mitotic errors, mutations and DNA repair 9. Growth factors, their receptors and proliferative pathways 10. Angiogenesis 11. Hypoxia in cancer 12. The Unique Metabolism of Cancer Cells - Part 1: Carbohydrates 13. The Unique Metabolism of Cancer Cells - Part 2: 14. The Unique Metabolism of Cancer Cells - Part 3: 15. The Unique Metabolism of Cancer Cells - Part 4: Iron metabolism in cancer 16. Molecular mechanisms of action of chemotherapeutic drugs 17. ROS and cancer 18. Targeted Cancer Treatments - Part I 19. Targeted Cancer Treatments - Part II: Antibody Drug Conjugates for cancer treatment: present and future 20. Cancer and the immune system - Part I 21. Cancer and the immune system - Part II 22. Cancer and the immune system - Part III: Some caveats about immunology and cancer. A historical and clinical perspective 23. The tumor microenvironment - Part I: Cancer environment and Groucho Marx’s principles 24. The tumor microenvironment - Part II: CELLS IN THE TUMOR MICROENVIRONMENT 25. The tumor microenvironment - Part III: Non-cellular components of the tumor microenvironment 26. The tumor microenvironment - Part IV: Adhesion molecules 27. The tumor microenvironment - Part V: Cytokines 28. The tumor microenvironment - Part VI: Chemokines in the TME 29. Tumor heterogeneity: A different way of looking at cancer 30. Resistance to treatment and multidrug resistance (MDR) 31. Pancreatic cancer: a paradigm of difficulties and drug resistance 32. Cancer cachexia 33. Tumor markers 34. The origins and pathogenesis of cancer 35. Extracellular vesicles: Exosomes and microvesicles in cancer. A message in a bottle. 36. Cancer stem cells 37. Repurposing drugs and nutraceuticals for cancer treatment - PART 1: General Concept 38. Repurposing drugs and nutraceuticals for cancer treatment - PART 2: Repurposable Drugs 39. Repurposing drugs and nutraceuticals for cancer treatment - PART 3 Repurposing Metformin 40. Repurposing drugs and nutraceuticals for cancer treatment - PART 4 Repurposable Nutraceuticals 41. The metabolic control center: a survival hub for normal and cancer cells 42. pH homeostasis and ion channels in cancer 43. Tumor growth and genetic evolution - Part I: Tumor growth and kinetics 44. Protein degradation in cancer - Part 1 45. Protein degradation in cancer - Part II : The unfold protein response (UPR) 46. Cell migration in cancer - Part I: mechanisms of migration and invasion 47. Cell migration in cancer - Part II: Targeting cancer cell migration and invasion 48. Cell migration in cancer - Part III: The "go or grow" hypothesis and some caveats 49. RNA in cancer - Part I: MicroRNAs MiRs or miRNAs 50. RNA in cancer - Part II: Long non-coding RNA (lncRNA) 51. RNA in cancer - Part III: RNA binding proteins (RBPs) 52. Epigenetics and cancer 53. Peroxisome, peroxisome proliferators and peroxisome proliferator-activated receptors in cancer 54. The renin-angiotensin system signaling pathways and cancer: two sides of the same coin 55. Hormone-dependent cancer 56. Chapter 34 Part 1: Cancer and inflammation 57. Chapter 34 part 2: Links between inflammation and cancer 58. Chapter 34 part 3: Caveats about anti-inflammatory drugs and cancer 59. Summary and final words
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