Chemotherapy Induced Nausea And Vomiting remains a common adverse event that has a huge impact on the lives of patients with cancer. Seventy to eighty percent of patients undergoing chemotherapy experience emesis, which could lead to deterioration in quality of life. Controlling emesis requires specialized skill collaborated with experience of physicians and other healthcare professionals to optimize clinical outcomes. The goal in the treatment requires a good knowledge on anti-emetics, experience to use them in combination which should be based on the severity, co- morbidity, pharmacodynamic and other pharmacological properties of the drugs to be prescribed.