Analysis and Purification Methods in Combinatorial Chemistry

Herausgegeben von Yan, Bing

• Gebundenes Buch

Produktbeschreibung

One of the most exciting analytical events in the past decade is the rapid development of combinatorial chemistry. Analysis and Purification Methods in Combinatorial Chemistry delivers the latest in this fast-moving field. Part one of the book describes various approaches to monitor reactions on solid support and optimize reactions for library synthesis. Part two is dedicated to high-throughput analytical methods used to analyze the quality of the libraries. Part three discusses various high-throughput purification techniques. Part four applies analytical methods to post-synthesis and post-purification stages. The book contains contributions from the field's most-respected researchers and practitioners.

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Quality measurement, control, and improvement in combinatorial chemistry
Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable."
To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering:
_ Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis
_ High-throughput analytical methods used to analyze the quality of libraries
_ High-throughput purification techniques
_ Analytical methods applied in post-synthesis and post-purification stages
Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques.
This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.

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Produktdetails

• Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 496
• Erscheinungstermin: 15. Dezember 2003
• Englisch
• Abmessung: 240mm x 159mm x 27mm
• Gewicht: 751g
• ISBN-13: 9780471269298
• ISBN-10: 0471269298
• Artikelnr.: 14909630

Autorenporträt

BING YAN, PhD, was born in China and received his PhD in chemistry at Columbia University in 1990. He then worked at Cambridge University and the University of Texas-Houston Medical School as a postdoctoral fellow. From 1993 to 1999, he worked for Novartis in the Core Technologies area of preclinical research in New Jersey. He is currently at the Discovery Chemistry division of Discovery Partners International, Inc., in San Francisco. His major research interests are drug discovery, optimization of solid-phase and solution-phase combinatorial synthesis, high-throughput quantitative and qualitative analysis, and high-throughput purification of combinatorial libraries. He has written four books and published over seventy reviews and research articles.

Inhaltsangabe

Preface.
Contributors.
PART I: ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS.
Chapter 1. Quantitative Analysis in Organic Synthesis with NMR (L. Lucas &
C. Larive).
Chapter 2. 19F Gel-phase NMR Spectroscopy for Reaction Monitoring and
Quantification of Resin Loading (J. Salvino).
Chapter 3. The Application of Single-Bead FTIR and Color Test for Reaction
Monitoring and Building Block Validation in Combinatorial Library
Sysnthesis(J. Cournoyer, et al.).
Chapter 4. HR-MAS NMR Analysis of Compounds Attached to Polymer Supports
(M. Guinó & Y. de Miguel).
Chapter 5. Multivariate Tools for Real-Time Monitoring and Optimization of
Combinatorial Materials and Process Conditions (R. Potyrailo, et al.).
Chapter 6. Mass Spectrometry and Soluble Polymeric Supports (C. Enjalbal,
et al.).
PART II: HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL.
Chapter 7. High-Throughput NMR Techniques for Combinatorial Chemical
Library Analysis (T. Hou & D. Raftery).
Chapter 8. Micellar Electrokinetic Chromatography as a Tool for
Combinatorial Chemistry Analysis: Theory and Applications (P. Simms).
Chapter 9. Characterization of Split-Pool Encoded Combinatorial Libraries
(J. Zhang & W. Fitch).
PART III: HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY.
Cha pter 10. Strategies and Methods for Purifying Organic Compounds and
Combinatorial Libraries (J. Zhao, et al.).
Chapter 11. HTP of Combinatorial Chemistry Libraries (J. Hochlowski).
Chapter 12. Practical HPLC in High Throughput Analysis and Purification (H.
Gumm & R. God).
PART IV: ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY.
Chapter 13. Organic Compound Stability in Large, Diverse Phatmaceutical
Screening Collection (K. Morand & X. Cheng).
Chapter 14. Quartz Crystal Microbalance in Biomolecular Recognition (M.
Tseng, et al.).
Chapter 15. High-Throughput Physicochemical Profiling: Potential and
Limitations (B. Faller).
Chapter 16. Solubility in the Design of Combinatorial Libraries (C.
Lipinski).
Chapter 17. High-Throughput Determination of Log D Values by LC/MS Method
(J. Villena, et al.). 
Index.