This study is an attempt to study the determinants of nutritional status of adolescents in Jimma zone using data from longitudinal family survey of youth. The survey collected information from a total of 2084 adolescents aged from 13 to 17 years in Jimma zone. Depending on the objectives of the study, Univariate and multivariate linear regression statistical techniques were used for data analysis using socio-economic, demographic and health variable as explanatory variables and measures of nutritional status with underweight and stunting as response variables. The results of the analysis showed place of residence, sex of adolescent and working in a job were the most important determinants of adolescents nutritional status in Jimma zone.