Integrating information systems (IS) into industrial operations is vital for improving efficiency, accuracy, and decision-making. This case study examines the Yemen Petroleum Company (YPC), focusing on its Aden branch and the potential for developing an effective IS. It highlights the significance of information technology in economic and social development and discusses the long-term benefits of IS.The Book includes a literature review that outlines YPC's history and strategic goals. It explores key IS functions like data collection and analysis, applying theoretical frameworks from established researchers. Six Sigma methodologies, especially the DMAIC process, are utilized to enhance IS quality and performance.Data were gathered from a questionnaire targeting IT staff, revealing common challenges such as security issues and integration difficulties. Performance evaluations indicate a pressing need for improvements.The study concludes with recommendations for enhancing IS performance and emphasizes the importance of continuous monitoring to ensure stability and efficiency, underscoring the necessity of robust IS frameworks at YPC for organizational success.